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| ID | Type | Description | Link |
|---|---|---|---|
| 2016-A00043-48 | Other Identifier | 2016-A00043-48 |
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| Name | Class |
|---|---|
| ONAPS : Observatoire National de l'Activité Physique et de la Sédentarité | UNKNOWN |
Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle which permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity.
The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training).
This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2.. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition.
40 obese adolescents will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2 weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric and isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Concentric cycling exercise (CON) | Experimental | 40 obese adolescents will be randomized into 2 groups: CON or EXC |
|
| eccentric cycling exercise (EXC) | Experimental | 40 obese adolescents will be randomized into 2 groups: CON or EXC |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cycling exercises | Other | All measurements are performed before and after the training program (12 weeks) |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in total body fat mass (Dual X ray Absorptiometry) | before and after the 12 weeks training program |
| Measure | Description | Time Frame |
|---|---|---|
| aerobic capacities (VO2max) | before and after the 12 weeks training program | |
| isometric muscular lower limbs strength | before and after the 12 weeks training program | |
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Inclusion Criteria:
Exclusion Criteria:
-
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Patrick LACARIN | Contact | 04 73 75 11 95 | placarin@chu-clermontferrand.fr |
| Name | Affiliation | Role |
|---|---|---|
| Valérie JULIAN | University Hospital, Clermont-Ferrand | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Clermont-Ferrand | Recruiting | Clermont-Ferrand | 63003 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38376518 | Derived | Moore H, Pereira B, Fillon A, Miguet M, Masurier J, Beaulieu K, Finlayson G, Thivel D. The association between obesity severity and food reward in adolescents with obesity: a one-stage individual participant data meta-analysis. Eur J Nutr. 2024 Jun;63(4):1241-1255. doi: 10.1007/s00394-024-03348-4. Epub 2024 Feb 20. | |
| 33121896 | Derived |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D063766 | Pediatric Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| isokinetic muscular lower limbs strength |
| before and after the 12 weeks training program |
| rest energy expenditure (indirect calorimetry) | before and after the 12 weeks training program |
| biological parameters (plasma lipid profile and insulin-resistance ) | before and after the 12 weeks training program |
| physical activity (actimetry and questionnaires) | before and after the 12 weeks training program |
| food intakes (measurements and questionnaires) | before and after the 12 weeks training program |
| quality of life (questionnaires) | before and after the 12 weeks training program |
| segmental body composition (segmental fat and fat free mass, Dual X-ray Absorptiometry) | before and after the 12 weeks training program |
| Julian V, Thivel D, Miguet M, Brengues C, Pereira B, Courteix D, Richard R, Duclos M. Bone response to eccentric versus concentric cycling in adolescents with obesity. Obes Res Clin Pract. 2020 Nov-Dec;14(6):554-560. doi: 10.1016/j.orcp.2020.10.002. Epub 2020 Oct 26. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |