Closed Loop Auditory Stimulus in Sleep and epilepsY | NCT05159609 | Trialant

Closed Loop Auditory Stimulus in Sleep and epilepsY | NCT05159609 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Stim First	Active Comparator	Participants slept for one night while auditory sounds were played at specific points during slow wave sleep. At least one week later, an identical procedure occured with no acoustic sounds.	Device: Closed loop auditory stimulus
Sham First	Sham Comparator	Participants slept for one night while no acoustic sounds were played. At least one week later, an identical procedure occured while acoustic sounds were played at specific points during slow wave sleep.	Device: Closed loop auditory stimulus

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Change in EEG waveform amplitude	Does the acoustic sound delivery alter EEG waveform amplitude of slow wave sleep	5 seconds after stimulus
Change in Serial Reaction Time Task memory test	Does the delivery of acoustic sounds alter post-sleep preformance on the above task	Baseline and following day
Change in Paired Associates Learning memory test	Does the delivery of acoustic sounds alter post-sleep preformance on the above task	Baseline and following day

Contacts/Locations Module

Overall Officials

Name	Affiliation	Role
Khalid Hamandi, MRCP/Phd	University Hospital of Wales/Cardiff University	Principal Investigator
Jennifer Roebber, PhD	University Hospital of Wales/Cardiff University	Principal Investigator

Condition Browse Module