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| Name | Class |
|---|---|
| Beijing Tongzhou Yongshun Community Health Service | UNKNOWN |
| Beijing Tongzhou Lucheng Community Health Service | UNKNOWN |
| Beijing Tongzhou Xuxinzhuang Community Health Service | UNKNOWN |
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Long-term Impact of Overweight/Obesity and Hypertension on Cardiovascular Risk in Middle-aged and Elderly Adults
Overweight and obesity are major risk factors associated with the development of hypertension, poor blood pressure control, and adverse cardiovascular outcomes. However, evidence regarding the long-term impact of overweight/obesity and hypertension on cardiovascular risk in middle-aged and elderly populations remains limited. Therefore, the present study aims to evaluate the long-term effects of overweight/obesity and hypertension on cardiovascular risk in middle-aged and elderly adults.Additionally, a subgroup analysis will be conducted in participants with sarcopenia to assess the influence of blood pressure on prognosis, exploring potential interactions between muscle loss, hypertension, and cardiovascular outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Obese hypertensive group | Patients who were diagnosed with obesity (body mass index (BMI)≥28kg/m2) and hypertension (systolic blood pressure (SBP)/diastolic blood pressure (DBP) ≥ 140/90 mmHg). |
| |
| Overweight hypertensive group | Overweight patients (24 kg/m2≤BMI≤28 kg/m2) diagnosed with hypertension (SBP/DBP≥140/90 mmHg). |
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| Lean hypertensive group | Lean patients (BMI ≤ 24 kg/m2) diagnosed with hypertension (SBP/DBP ≥ 140/90 mmHg). |
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| Lean normotensive | Lean patients (BMI ≤ 24 kg/m2) diagnosed with normotensive (SBP/DBP < 140/90 mmHg). |
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| Overweight normotensive | Overweight patients (24 kg/m2≤BMI≤28 kg/m2) diagnosed with normotensive (SBP/DBP<140/90 mmHg) |
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| Obese normotensive | Patients who were diagnosed with obesity (BMI≥28kg/m2) and normotensive (SBP/DBP<140/90 mmHg). |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | This is an observational study without any intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of participants with major adverse cardiovascular events (MACEs) | Percentage of participants with major adverse cardiovascular events (MACEs), including all-cause death, nonfatal myocardial infarction (MI), nonfatal stroke and coronary revascularization. | 2021-2026 |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of participants with all-cause death | Percentage of participants with cardiovascular, non-cardiovascular and undetermined death. | 2021-2026 |
| Percentage of participants with MI | Percentage of participants with fatal and nonfatal MI. |
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Inclusion Criteria:
Exclusion Criteria:
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Adults undergoing routine physical examinations at community health service centers in Tongzhou, China.
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| Name | Affiliation | Role |
|---|---|---|
| Rongchong Huang, M.D. | Beijing Friendship Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Friendship Hospital, Capital Medical University | Beijing | Beijing Municipality | 100050 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38047735 | Derived | Wang G, Zhao Y, Li Z, Li D, Zhao F, Hao J, Yang C, Song J, Gu X, Huang R. Association between novel inflammatory markers and non-alcoholic fatty liver disease: a cross-sectional study. Eur J Gastroenterol Hepatol. 2024 Feb 1;36(2):203-209. doi: 10.1097/MEG.0000000000002686. Epub 2023 Dec 1. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| 2021-2026 |
| Percentage of participants with stroke | Percentage of participants with fatal and nonfatal stroke. | 2021-2026 |
| Percentage of participants undergoing coronary revascularization | Percentage of participants undergoing ischemia- and non-ischemia-driven coronary revascularization. | 2021-2026 |
| Change in BP control rate | Change in BP control rate (office BP: SBP < 140 mmHg and DBP < 90 mmHg) from baseline to follow-up. | 2021-2026 |
| Change in SBP | Change in SBP from baseline to follow-up. | 2021-2026 |
| Change in estimated glomerular filtration rate (eGFR) | Change in estimated glomerular filtration rate (eGFR) in ml/min/1.73m2 from baseline to follow-up. | 2021-2026 |
| Change in low-density lipoprotein-cholesterol (LDL-c) | Change in low-density lipoprotein-cholesterol (LDL-c) in mmol/L from baseline to follow-up. | 2021-2026 |
| Percentage of participants with Metabolic dysfunction-associated steatotic liver disease (MASLD) | Percentage of participants with Metabolic dysfunction-associated steatotic liver disease. | 2021-2026 |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |