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The investigators aimed to evaluate the efficacy of PDRN administration in early wound healing phase on prevention of post-operative scars after open thyroidectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PDRN injected group | Experimental | The participants in treatment group had received two consecutive injections of PDRN one day and two days after the surgery. A total 1mL of PDRN was injected along the suture line at distance of 1cm in each session. |
|
| Control group | No Intervention | The participants in control group were left untreated. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Polydeoxyribonucleotide (PDRN) | Procedure | A total 1mL of PDRN was injected along the suture line at distance of 1cm in one day and two days after the surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| modified Vancouver Scar Scale (0 normal skin~15 worst) at the 3-month follow-up | modified Vancouver Scar Scale (0 normal skin~15 worst) | at 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective symptoms at the 3-month follow-up | Pain and itching were assessed using a visual analog scale (VAS) ranged from 0 (no) to 10 (worst). | at 3 months |
| Erythema and pigmentation at the 3-month follow-up |
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Inclusion Criteria:
• Participants who underwent open thyroidectomy between February 2019 and March 2021 at the Thyroid Cancer Center, Department of otorhinolaryngology, Seoul National University Bundang Hospital
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jung Won Shin, M.D., Ph.D. | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam | 13620 | South Korea |
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| ID | Term |
|---|---|
| D002921 | Cicatrix |
| ID | Term |
|---|---|
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D011089 | Polydeoxyribonucleotides |
| ID | Term |
|---|---|
| D011119 | Polynucleotides |
| D009711 | Nucleotides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
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Erythema Index (EI, arbitrary unit) and the Melanin Index (MI,arbitrary unit)
| at 3 months |
| Scar Height (mm) at the 3-month follow-up | 3D images of the scars were acquired with an Antera 3D® camera (Miravex Limited, Dublin, Ireland) | at 3 months |