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Banana peel has the potential to improve sleep quality. The purpose of this research is to test the effect of banana peel on improving sleep quality.
Insomnia is one of the most frequently complained sleep problems in sleep disorders, and in recent years has been regarded by the medical community as a disease that seriously affects people's lives and quality of life. The problem of perishable and perishable causes a great burden on the environment. However, banana peels actually contain many functional ingredients, such as dietary fiber, minerals, alkaloids, flavonoids, phenols, saponins, tannins and dopamine, etc. Banana peel contains more total phenols and total flavonoids than banana pulp. Studies have pointed out that banana peel extraction can inhibit the growth of fungi and bacteria. In addition, it also has antioxidant, anti-depressant, and diuretic functions. Banana peel can also improve the performance of tryptophan metabolism-related genes
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | take 2 tablets 2 hours before bedtime for 4 consecutive weeks |
|
| Banana peel extract | Experimental | take 2 tablets 2 hours before bedtime for 4 consecutive weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement | take 2 tablets 2 hours before bedtime for 4 consecutive weeks |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Sleep monitoring | Detect the electrical activity of the heart in the potential difference between two specific points on the body surface to reflect the state of sleep | at 4 week after taking test sample |
| Serotonin | Venous blood was sampled to measure concentrations of Serotonin | at 4 week after taking test sample |
| Melatonin | Collect saliva samples in the morning upon waking to measure melatonin concentration. | at 4 week after taking test sample |
| Sleeping quality | The Pittsburgh Sleep Quality Index (PSQI) will be utilized to assess sleeping quality. The minimum value is 0, the maximum value is 42. The higher the score, the worse the outcome. | at 4 week after taking test sample |
| Insomnia Severity | The Insomnia Severity Index (ISI) will be utilized to assess insomnia severity. The minimum value is 0, the maximum value is 28. The higher the score, the worse the outcome. | at 4 week after taking test sample |
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| Measure | Description | Time Frame |
|---|---|---|
| The change of liver function biomarkers (AST, ALT) of blood | Fasting venous blood was sampled to measure liver function biomarkers | at 4 week after taking test sample |
| The change of renal function biomarkers (creatinine, BUN) of blood |
Inclusion Criteria:
1.20 to 65-year-old males or non-pregnant females who are willing to sign the subject's consent.
2.Pittsburgh Sleep Quality Index (PSQI) score> 5
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hsin-Chien Lee, Doctor | Taipei Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Taipei Medical University | Taipei | Taiwan |
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| Banana peel extract |
| Dietary Supplement |
take 2 tablets 2 hours before bedtime for 4 consecutive weeks |
|
|
Fasting venous blood was sampled to measure renal function biomarkers
| at 4 week after taking test sample |
| The change of fasting blood glucose | Fasting venous blood was sampled to measure concentrations of blood glucose | at 4 week after taking test sample |
| The change of Blood lipids profiles (Total-Cholesterol, HDL-C, LDL-C, triglycerides) | Fasting venous blood was sampled to measure concentrations of Blood lipids profiles (Total-Cholesterol, HDL-C, LDL-C, triglycerides) | at 4 week after taking test sample |