The Sleep Improving Effects of Orange Phenolics

Determination of the Sleep Improving Effects of Phenolics From an Orange Peel Extract

This study aims to determine whether a citrus flavonoid or a citrus flavonoid formulation can improve objective sleep duration and/or quality, and/or improve perceived sleep quality and feelings of rest.

Participants will complete a total of 9 test nights, which consist of sleeping with the sleep monitoring system after ingestion of the test product or a placebo, and filling out sleep-related questionnaires.

The study has a crossover design, meaning that all participants receive all three interventions (citrus flavonoid, citrus flavonoid formulation, placebo) three times, in a randomized order.

Inclusion Criteria:

• Age 18-75
• Non-smoking
• Healthy
• Lightly disturbed sleep for at least six months, on a regular basis

Exclusion Criteria:

• Severe sleep disorders (sleep apnea, restless legs syndrome)
• An apparent cause for the sleep disorders (pain, etc.)
• Clinically significant abnormal liver functioning
• Clinically significant abnormal serum creatinine
• BMI lower than 18 or higher than 30 kg/m2
• Use of concomitant medications or supplements