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In this study, the bioavailability of a specific orange peel extract is tested. The composition and morphology of the test product is altered compared to the generic product, which is used as a control. Due to intellectual property issues, more information cannot be given at this moment. Also the difference in bioavailability between a capsule and a lozenge is tested. The hypothesis is that the bioavailability of the altered extract will be improved compared to the control.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| phenolics form orange peel, type 1 | Active Comparator | 1 dose of 500 mg of phenolics from orange peel, orally ingested |
|
| phenolics from orange peel, type 2 | Active Comparator | 1 dose of 500 mg of phenolics from orange peel, orally ingested |
|
| phenolics from orange peel, type 3 | Experimental | 1 dose of 500 mg of phenolics from orange peel, orally ingested |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| phenolics form orange peel | Dietary Supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| plasma concentrations of specific phenolics and their metabolites | up to 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| urine concentrations of specific phenolics and their metabolites | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Chris Van der Grinten, PhD | Maastricht University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maastricht University Medical Centre | Maastricht | 6229ER | Netherlands |
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