This is a multi-center, randomized, controlled trial study to find whether use of chlorhexidine-alcohol or povidone-iodine for pre-vaginal delivery skin prep is superior to reduce postpartum infection in pregnant women with vaginal delivery. The primary outcome is the episiotomy site infection.

Inclusion Criteria:

• Women with singleton pregnancy
• Women who will undergo vaginal delivery after 37+0/7 weeks of gestation

Exclusion Criteria:

• Women who are allergy to chlorhexidine, alcohol, iodine, or shellfish
• Women with any infection at perineum (before vaginal delivery)