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| Name | Class |
|---|---|
| Medical University of Gdansk | OTHER |
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The primary aim of the current research project is to explore whether carnitine supplementation and resistance training may prevent decrements in bone mineral density of aged women.
A secondary aim of this project is to investigate the effect of supplementation on body composition and blood markers.
The study includes postmenopausal women. The subjects participate in resistance training (twice a week) for each session consisted of 6 exercises: horizontal seated leg press, seated chest press, leg extension, shoulder press, lat pull-down seated row, seated cable row.
During the 24-weeks training programme participants are supplemented by carnitine with leucine, or leucine alone (placebo).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| carnitine + leucine | Experimental | 1000 mg L-carnitine with 3000 mg L-leucine per day for 24 weeks |
|
| leucine | Placebo Comparator | 4000 mg L-leucine per day for 24 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L-carnitine | Dietary Supplement | L-carnitine-L-tartrate |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Bone Mineral Density measured by dual-energy X-ray absorptiometry (DXA) | Bone mineral density (BMD) of the femoral neck, lumbar vertebrae L1-L4, and total hip determined by Lunar Prodigy Advance DXA (GE, Healthcare, Madison, Wisconsin, USA). | 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Body Composition: Body Fat Mass, Fat Free Mass, and Skeletal Muscle Mass using a bioelectrical impedance analyzer (InBody720). | The InBody720 measures impedance of five segments of the body (each arm, each leg, trunk) at frequencies of 1, 5, 50, 250, 500, and 1000 kHz through the 8-polar tactile-electrode. Based on the impedance, body fat mass, fat free mass, and skeletal muscle mass are calculated. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Robert Olek, PhD | Poznan University of Physical Education | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Akademia Wychowania Fizycznego | Poznan | 61-871 | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37533033 | Derived | Olek RA, Samborowska E, Wisniewski P, Wojtkiewicz P, Wochna K, Zielinski J. Effect of a 3-month L-carnitine supplementation and resistance training program on circulating markers and bone mineral density in postmenopausal women: a randomized controlled trial. Nutr Metab (Lond). 2023 Aug 2;20(1):32. doi: 10.1186/s12986-023-00752-1. |
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| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D002331 | Carnitine |
| D007930 | Leucine |
| ID | Term |
|---|---|
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
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| L-leucine |
| Dietary Supplement |
L-leucine |
|
| 24 weeks |
| The circulating markers modification | Determination of serum interleukin-6, tumor necrosis factor alpha, C-reactive protein, and plasma trimethylamine N-oxide. | 24 weeks |
| D009750 |
| Nutritional and Metabolic Diseases |
| D000597 |
| Amino Acids, Branched-Chain |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000601 | Amino Acids, Essential |