Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The project is designed as a cross-sectional study and aims to examine long-term consequences of coronavirus disease 2019 (COVID-19) for selected bio-behavioural parameters while taking the disease course severity into account.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COVID-19 (18 months post-infection) | Individuals with a positive Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) antigen-/polymerase chain reaction (PCR) test within the last 18 months that required hospitalisation. Symptoms typically worsened within a period of 5 to 10 days leading to e.g., prolonged fever, feeling of sickness and/or shortness of breath. This also includes individuals hospitalised in an intensive care ward. Individuals need to be hospitalised due to COVID-19 and not only with COVID-19. |
| |
| Control group | Age-, sex-, and comorbidity-matched (frequency matching), fully vaccinated individuals with no history of symptomatic SARS-CoV-2 infection. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiorespiratory fitness | Diagnostic Test | Cardiopulmonary exercise testing |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cardiorespiratory fitness (as % of predicted V̇O2max) | Measured during cardiopulmonary exercise testing on a cycle ergometer. | 1.5 hours after inclusion in study |
| Measure | Description | Time Frame |
|---|---|---|
| Forced expiratory volume in 1 s (as % of predicted) | Measured during bodyplethysmography. | 1.5 hours after inclusion in study |
| Forced vital capacity (as % of predicted) | Measured during bodyplethysmography. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Previously hospitalised patients recovering from COVID-19 and fully vaccinated controls with no history of symptomatic COVID-19.
Recruitment of patients will be done via the University Hospital of Basel, Switzerland, the Clinic Barmelweid, Barmelweid, Switzerland, and Cantonal Hospital Olten, Olten, Switzerland. Participants for the control group will be recruited prospectively through unaddressed letters distributed in the Basel-Stadt area, newspaper, internet-based media, and word-of-mouth. Recruitment will continue until the number of valid datasets corresponds to the calculated sample size.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Arno Schmidt-Trucksäss, Prof. | Contact | +41 61 207 47 40 | arno.schmidt-trucksaess@unibas.ch |
| Name | Affiliation | Role |
|---|---|---|
| Arno Schmidt-Trucksäss, Prof. | Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Division of Sports and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel | Recruiting | Basel | Canton of Basel-City | 4052 | Switzerland |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Blood samples (total volume 36 mL) will be collected by venipuncture of the cubital fossa, are subsequently centrifuged and the plasma aliquots are frozen at -80°C.
| Lung function | Diagnostic Test | Body plethysmography |
|
| Muscular strength and balance tests | Diagnostic Test | Handgrip strength test, mid-thigh pull test and standing balance test in static tandem stance |
|
| Micro- and macrovascular endothelial function and cardiac function | Diagnostic Test | Measurement of flow-mediated dilation, static and dynamic retinal vessel analysis, echocardiography |
|
| Blood sampling and analysis | Diagnostic Test | Blood sampling by venepuncture |
|
| Physical activity | Diagnostic Test | Physical activity surveillance using accelerometers |
|
| Questionnaires | Diagnostic Test | Global physical activity questionnaire (GPAQ), short-form 8 health survey (SF-8), barriers to physical activity, fatigue assessment scale (FAS), modified medical research council dyspnea scale (mMRC), depression, anxiety, and stress scale (DASS21), post-COVID-19 syndrome symptoms |
|
| Body composition | Diagnostic Test | Dual-energy x-ray absorptiometry (DXA) |
|
| 1.5 hours after inclusion in study |
| Total lung capacity (as % of predicted) | Measured during bodyplethysmography. | 1.5 hours after inclusion in study |
| Diffusion capacity of the lungs (as % of predicted) | Measured during bodyplethysmography. | 1.5 hours after inclusion in study |
| Muscle oxygenation at peak exercise (in %) | Measured using near-infrared spectroscopy during cardiopulmonary exercise testing on a cycle ergometer. | 1.5 hours after inclusion in study |
| Cardiac output at peak exercise (in mL) | Measured non-invasive using the PhysioFlow device during cardiopulmonary exercise testing on a cycle ergometer. | 1.5 hours after inclusion in study |
| Handgrip strength (in N) | Measured by a handheld dynamometer. | 1 hour after inclusion in study |
| Handgrip rate of force development (in N/s) | Measured by a handheld dynamometer. | 1 hour after inclusion in study |
| Macrovascular flow-mediated dilation at rest (in %) | Measured by ultrasound. | 0.5 hours after inclusion in study |
| Microvascular flow-mediated dilation at rest (in %) | Measured by retinal vessel analysis. | 2 to 14 days after inclusion in study |
| Fatigue Assessment Scale (FAS) score | Scores range from 5 to 50 with higher scores indicating more severe fatigue. | 2 to 14 days after inclusion in study |
| Score of depression, anxiety, and stress questionnaire (DASS21) | Scores range from 0 to 63 with higher scores indicating worse mental health. | 2 to 14 days after inclusion in study |
| Health distance | The statistical (Mahalanobis) distance (health distance) is a composite measure of various health biomarkers | Calculated during statistical analysis |
| Cerebral oxygenation at peak exercise (in %) | Measured using functional near-infrared spectroscopy during cardiopulmonary exercise testing on a cycle ergometer. | 1.5 hours after inclusion in study |
| ID | Term |
|---|---|
| D018352 | Coronavirus Infections |
| ID | Term |
|---|---|
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D007239 | Infections |
Not provided
Not provided
| ID | Term |
|---|---|
| D000072599 | Cardiorespiratory Fitness |
| D012119 | Respiration |
| D001800 | Blood Specimen Collection |
| D015444 | Exercise |
| D001823 | Body Composition |
| ID | Term |
|---|---|
| D010809 | Physical Fitness |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D006262 | Health |
| D011154 | Population Characteristics |
| D012143 | Respiratory Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D009043 | Motor Activity |
| D009068 | Movement |
| D001669 | Biochemical Phenomena |
| D055598 | Chemical Phenomena |
| D008660 | Metabolism |
| D001824 | Body Constitution |
| D010829 | Physiological Phenomena |
Not provided
Not provided