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This research study is being done to find out what the longer-term physiological consequences of COVID-19 are, and to determine if exercise therapy can help improve lung function, heart function and overall fitness, and reduce symptoms in people recovering from SARS-CoV-2.
The purpose of this research is to see if taking part in structured exercise training will improve the ability to exercise, the function of the lungs and the function of the heart, and reduce symptoms of fatigue and breathlessness in people recovering from COVID-19. After enrollment all patients will complete exercise testing, lung function testing, and cardiac imaging. Patients will be randomized to either 8 weeks of exercise training (4-5 times per week) or will continue standard medical care. All patients will undergo detailed exercise testing, lung function testing, and cardiac imaging after the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | No Intervention | Standard physician-guided medical care after COVID-19 | |
| Interventional (exercise training) Group | Experimental | 8 week home-based exercise training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise Training | Other | 8 week home-based exercise therapy 4-5 times/week |
|
| Measure | Description | Time Frame |
|---|---|---|
| Maximal oxygen update (VO2max) measured in mL/kg/min | VO2max is the maximal oxygen consumed during an exhaustive exercise test | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Peak exercise work rate (Wpeak) measured in Watts | Wpeak is the highest achieved power during a maximal incremental cycle exercise test | 8 weeks |
| Forced vital capacity (FVC) measured in L | FVC is the largest amount of air that can be exhaled from the lungs in one maximal breath |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bryan Taylor, PhD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Florida | Jacksonville | Florida | 32224 | United States |
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| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| 8 weeks |
| Forced expiratory volume in 1 second (FEV1) measured in L | FEV1 is the largest amount of air that can be exhaled from the lungs in the first second of one maximal breath | 8 weeks |
| Maximal inspiratory pressure (MIP) measured in cmH2O | Highest inspiratory muscle pressure (i.e. inspiratory muscle strength) during a maximal inspiratory effort | 8 weeks |
| Maximal expiratory pressure (MEP) measured in cmH2O | Highest expiratory muscle pressure (i.e. expiratory muscle strength) during a maximal expiratory effort | 8 weeks |
| Left ventricular contractile function measured as % fractional area change (LV FAC) | LV FAC is a measure of overall contractile function of the LV | 8 weeks |
| Right ventricular contractile function measured as % fractional area change (RV FAC) | RV FAC is a measure of overall contractile function of the RV | 8 weeks |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |