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Pulmonary Langerhans cell histiocytosis (PLCH) is a rare disease, of unknown etiology, that occurs almost exclusively in smokers.The clinical experience suggests a high prevalence of anxiety symptoms and an addictive profile. However, no study to date has precisely investigated the prevalence of co-morbid psychiatric disorders in this population.The aim of the study is to evaluate the prevalence of co-morbid psychiatric disorders in adult PLCH patients.
This study should allow:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pulmonary Langerhans cell histiocytosis (PLCH) | Adults with pulmonary Langerhans cell histiocytosis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Evaluation of co-morbid psychiatric disorders | Other | Added scales :
Additional dosage : - a urine sample will be taken to evaluate the presence of tobacco and nicotine breakdown products and the presence of various toxics Expired carbon monoxide for patients using nicotine substitutes |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients with at least one of the disorders detailed in the Mini International Neuropsychiatric Interview (MINI) test | The Mini-International Neuropsychiatric Interview (M.I.N.I.) is a structured diagnostic interview (40 minutes duration), exploring in a standardized way the main psychiatric disorders of Axis I of the DSM-IV TR (American Psychiatric Association), namely 14 items with a binary result for each specified disorder | at inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients with at least one comorbid addictive disorder among: tobacco, alcohol, cannabis, benzodiazepines, cocaine, opiates | Definition and diagnosis of addictive disorder will be assessed with Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) | at inclusion |
| Proportion of patients with active tobacco consumption with or without comorbid psychiatric disorder |
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Inclusion Criteria:
Exclusion Criteria:
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Adults with pulmonary Langerhans cell histiocytosis
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Abdellatif TAZI | Contact | +33142499618 | abdellatif.tazi@aphp.fr | |
| Matthieu Resche-Rigon, Pr | Contact | +33142499742 | matthieu.resche-rigon@u-paris.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Saint-Louis, Centre de référence national des histiocytoses, Service de Pneumologie | Paris | France |
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| ID | Term |
|---|---|
| D006646 | Histiocytosis, Langerhans-Cell |
| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D015614 | Histiocytosis |
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|
Tobacco consumption will be assessed by Fagerström survey and DSM-5, cotinine in urine quantification and expired carbon monoxide for patients using nicotine substitutes. Fargerstrom test evaluates the dependence on cigarettes from 0 to 10 (0 indicated a very low dependence and 10 a very strong dependence) |
| at inclusion |
| Proportion of patients with persistent tobacco consumption despite nicotine replacement treatment | Tobacco consumption will be assessed by Fagerström survey and DSM-5 and expired carbon monoxide for patients with nicotine substitutes | at inclusion |
| Number of previous tobacco weaning episodes and co-morbid psychiatric disorders | at inclusion |
| Number of co-morbid psychiatric disorders | at inclusion |
| Factors associated with psychiatric disorders as assessed by Mini International Neuropsychiatric Interview (MINI) test | The Mini-International Neuropsychiatric Interview (M.I.N.I.) is a structured diagnostic interview (40 minutes duration), exploring in a standardized way the main psychiatric disorders of Axis I of the DSM-IV TR (American Psychiatric Association), namely 14 items with a binary result for each specified disorder | at inclusion |
| D008206 |
| Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |