Prospective Evaluation of Adult Pulmonary Langerhans Cell Histiocytosis

Epidemiology of Adult Adult Pulmonary Langerhans Cell Histiocytosis - A Multicenter Cohort Study

Study objectives:

• To estimate the incidence of pulmonary deterioration in adult pulmonary Langerhans cell histiocytosis
• To assess the impact of tobacco discontinuation
• Study Design Multicentric prospective cohort study
• Main endpoint: Pulmonary deterioration
• Sample size : 40 patients

Study objectives To estimate the incidence of pulmonary deterioration in adult pulmonary Langerhans cell histiocytosis To assess the impact of tobacco discontinuation Study Design Multicentric prospective cohort study Main endpoint: Pulmonary deterioration Sample size : 40 patients

Inclusion Criteria:

• Pulmonary Langerhans cell histiocytosis diagnosed within the past 48 months

Exclusion Criteria:

• Age < 18
• Deep pulmonary dysfunction (CPT< 60%, FEV1< 30%, DLCO< 30%, partial pressure of oxygen in arterial blood (PaO2)< 60mmHg)
• No informed consent or consent withdrawal