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The aim of this cohort study is to record, evaluate and compare the surgical, oncological as well as the functional outcome and Quality of life after mesorectal excision for rectal cancer
Outcomes of mesorectal excision patients will be analysed. Medical records will be reviewed and perioperative outcomes retrieved, incl. long-term oncological and functional/quality of life data. A retrospective cohort over 10 years (2007-2016) will serve as a control to a prospective cohort over 10 further years (2017-2026) as to investigate trends in perioperative and oncological outcomes (min. follow-up of 5 years + adequate cohort size). Prospective data on bowel function, urogenital function and quality of life will measured at time of diagnosis and further. Variations in neoadjuvant/adjuvant treatment and surgical approaches will be assessed for their effect on the outcomes of interest.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TME for rectal cancer | Patients with rectal cancer treated by TME (laparoscopic TME, transanal TME, robotic TME, open TME) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Total mesorectal excision for rectal cancer | Procedure |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Perioperative mortality | Reporting perioperative mortality with Clavien-Dindo & Comprehensive Complications Index | 90 days |
| Age | Age (years) | 10 years |
| Body mass index | BM (kg/m2) | 10 years |
| Gender | Sex (male, female) | 10 years |
| ASA score | American Society of Anesthesiologists score (I to V) | 10 years |
| Date of surgery | date of surgery (day-month-year) | day of surgery |
| Tumor localisation | Description of tumor localisation | 10 years |
| Comorbidities | Charlson index | day of surgery |
| Perioperative complications | Reporting and grading of postoperative surgical complications (according to Dindo-Clavien classification and/or comprehensive complications index) |
| Measure | Description | Time Frame |
|---|---|---|
| Perioperative treatment | Chemoradiation before or after surgery, other treatments necessary | 10 years |
| Surgery time | Duration of surgery in minutes |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with rectal cancer who benefit from surgical resection
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michel Adamina, Prof/MD/MSc | Contact | +41522663376 | michel.adamina@ksw.ch | |
| Kantonsspital Winterthur | Contact |
| Name | Affiliation | Role |
|---|---|---|
| Michel Adamina, Prof/MD/MSc | Kantonsspital Winterthur KSW | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kantonsspital Winterthur | Recruiting | Winterthur | Canton of Zurich | 8401 | Switzerland |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| 90 days |
| Histological results | Histological staging and grading of the specimen by a pathologist | 30 days |
| Quality of life, including functional and symptom scales, incontinence scores, sexual function | taTME survey (validated english, german, french versions); from 0 (worst) to 100 (best) | 10 years |
| day of surgery |
| Length of hospital stay | Length of hospital stay in days | 90 days |
| Readmission rate | Number of patients readmitted within 90 days of index surgery divided by the total number of patients operated | 90 days |
| Costs | At the level of individual patient Cost in terms of hospital charges and expenses in Swiss Francs. Actual costs and micro-costing | 10 years |