Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| R01DK125417 | U.S. NIH Grant/Contract | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to determine how different behavioral interventions designed to alter food perceptions and behaviors affect brain responses to food, eating behaviors, and body weight.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active Implicit Priming | Experimental | Participants will complete active implicit priming, in which food images are implicitly primed (i.e., below conscious awareness) with images of positive or negative affect. This will be completed on a weekly basis for 12 weeks, for approximately 10 minutes each time. |
|
| Control Implicit Priming | Placebo Comparator | Participants will complete control implicit priming, which matches the active intervention, but with neutral stimuli as primes. This will be completed on a weekly basis for 12 weeks, for approximately 10 minutes each time. |
|
| Food Exposure Task | Active Comparator | Participants will complete a Food Exposure Task, in which they will be asked to smell, feel, lick, and imagine eating food items, but without actually eating them. This will be completed on a weekly basis for 12 weeks, for approximately 10-30 minutes each time. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Active Implicit Priming | Behavioral | Approximately 10-minute behavioral intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percent Change in Blood Oxygen Level Dependent (BOLD) Response to Visual Food Cues as Measured by Functional Magnetic Resonance Imaging | Percent change in blood oxygen level dependent (BOLD) response from baseline to after the 12-week intervention while viewing visual food cues will be measured using functional magnetic resonance imaging (fMRI), focusing on insula, striatum, and prefrontal cortex. | Baseline, 12 weeks |
| Change in Food Image Ratings | Food image ratings change from baseline to after the 12-week intervention. Food images are rated on "desire to eat" by visual analogue scale (0-100), with higher scores indicating greater desire to eat. | Baseline, 12 weeks |
| Change in Food Intake | Food intake change from baseline to after the 12-week intervention. Food intake will be measured as total calories consumed during an ad libitum meal. | Baseline, 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Percent Change in Body Weight | Percent change in body weight (kg) from baseline to after the 12-week intervention. | Baseline, 12 weeks |
| Change in Fat Mass | Change in fat mass, as measured using dual-energy x-ray absorptiometry, from baseline to after the 12-week intervention. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christina Erpelding, BS | Contact | 303-724-8502 | christina.erpelding@cuanschutz.edu | |
| Kristina Legget, PhD | Contact | 303-724-5809 | kristina.legget@cuanschutz.edu |
| Name | Affiliation | Role |
|---|---|---|
| Jason Tregellas, PhD | University of Colorado, Denver | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Anschutz Medical Campus | Recruiting | Aurora | Colorado | 80045 | United States |
Not provided
| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| D015431 | Weight Loss |
| D001835 | Body Weight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D012816 | Signs and Symptoms |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Control Implicit Priming | Behavioral | Approximately 10-minute behavioral intervention |
|
| Food Exposure Task | Behavioral | Approximately 10-30 minute behavioral intervention |
|
| Baseline, 12 weeks |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001836 | Body Weight Changes |