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An investigation of the change in inflammation marker levels across hip fracture surgery and an exploration of any association with change in self reported health status and incidence of postoperative delirium
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group | People age 65 years and older undergoing primary hip fracture surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hip fracture Surgery (Primary) | Procedure | Surgery for primary hip fracture requiring general or neuro-axial anaesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cytokine dynamics | Difference preoperative serum cytokine levels and postoperative serum cytokine levels in pg/mL. | 2 days |
| Incidence of postoperative delirium | Assessment for presence or absence of delirium during the post operative period. | 5 days |
| Measure | Description | Time Frame |
|---|---|---|
| Self reported health related quality of Life | Assessed preoperatively and again at approximately 120 days after surgery using the EuroQol Five Dimension Five level (EQ-5D-5L) tool. The tool assesses on five aspects of health (Dimensions) and each dimension has five possible levels. The tool also has a visual analogue scale ranging from 0 (poorest) to 100 (best health) | 120 days |
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Inclusion Criteria:
Exclusion Criteria:
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Patients age ≥ 65 years old presenting to hospital with a primary hip fracture
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Abiodun Noah, FRCA | Contact | 01158231011 | abi.noah@nottingham.ac.uk | |
| Iain Moppett, DM | Contact | 01158230959 | iain.moppett@nottingham.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Iain Moppett, DM | University of Nottingham | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Queen's Medical Centre | Recruiting | Nottingham | United Kingdom |
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| ID | Term |
|---|---|
| D000071257 | Emergence Delirium |
| ID | Term |
|---|---|
| D003693 | Delirium |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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Blood sample for Cytokine analysis
| D009422 |
| Nervous System Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |