Study of Postoperative Delirium in Elderly People After Orthopedic Surgery

microRNA and Delirium After Hip and Knee Fracture

The purpose of this study is to investigate the possible relationship of microRNA and postoperative delirium.

Postoperative delirium is one of the most common postoperative complications in elderly patients.It has been shown that postoperative delirium has independent adverse effects on short and long-term mortality and morbidity, including poor functional recovery, postoperative cognitive dysfunction, deterioration in quality of life, and increased costs. However, at the present time, postoperative delirium is a clinical phenomenon, and its neuropathogenesis remains unknown. This gap in knowledge has become a barrier that limits further studies, including the development of potential interventions for postoperative delirium.

Inclusion Criteria:

1. 65 years old or older
2. candidates for spinal anesthesia
3. Non language communication barriers

Exclusion Criteria:

1. past medical history of neurological and psychiatric diseases including AD, other forms of dementia, stroke, or psychosis;
2. severe visual or hearing impairment;
3. unwillingness to comply with the protocol or procedures.