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Acute pancreatitis (AP) is a one of the potentially life-threatening complication of severe hypertriglyceridemia (HTG), with mortality around to 30%.
HTG-associated PA and their complications management has to be the same as the other pancreatitis, but they are associated with the worse clinical outcomes. Triglycerides levels are correlated with the risk of pancreatitis and severity.
Therapeutic plasma exchange (TPE) could provide positive effects in reducing triglyceridemia plasma levels during the acute phase of HTG-AP, and in prevention of recurrence. There is currently no difference about mortality in studies. Some authors have recommended its use only in severe HTG-AP and have precised the need of early initiation to have positive results.
Despite such promising findings from studies, the effects of therapeutic plasma exchange on HTG-associated PA have never been specifically assessed and its benefits in critically ill patients with AP remains uncertain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| severe acute pancreatitis | Patients 18 years of age or older admitted to intensive care or resuscitation for severe acute pancreatitis (AP) with hypertriglyceridemia (HTG) |
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| Measure | Description | Time Frame |
|---|---|---|
| Mortality at Day 28 | Assess the factors on admission associated with the prognosis of patients admitted in ICU for HTG-associated PA. Factors associated with death at D28 will be considered individually for entry into a multivariate model. The following variables of interest will be tested in the model: SOFA score, triglyceride level at admission, obesity. | Day 28 |
| Measure | Description | Time Frame |
|---|---|---|
| Length of hospitalization | Describe length of stay in ICU and on hospital for patients admitted in ICU for HTG-associated PA | Day 28 |
| Use of organ support | Describe use of organ supports (vasopressors, extra-renal dialysis and mechanical ventilation) |
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Inclusion Criteria:
Exclusion Criteria : Patient without norepinephrine or missing data.
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Any patient hospitalized with severe acute pancreatitis of hypertriglycemic origin admitted to the ICU between January 2010 and January 2020.
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| Name | Affiliation | Role |
|---|---|---|
| stephanie Bulyez, MD, PhD | Centre Hospitalier Universitaire de Nīmes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nîmes - Hôpital Universitaire Carémeau | Nîmes | 30029 | France |
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| ID | Term |
|---|---|
| D010195 | Pancreatitis |
| D015228 | Hypertriglyceridemia |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
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| Day 28 |
| Assess benefit of plasmapheresis | Assess benefit of plasmapheresis for patients admitted in ICU for HTG-associated PA | Day 28 |
| D052439 |
| Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |