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To compare effectiveness in reducing triglycerides between daily plasma exchange and glucose+insulin infusion in patients with non-severe acute hypertriglyceridemic pancreatitis with mildly elevated triglycerides
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| plasma exchange | Experimental | plasma exchange, with 1.5 estimated plasma volume exchanged with albumin solution, using citrate anticoagulation, performed daily until triglycerides <=10 mmol/l |
|
| conservative treatment | Active Comparator | infusion of 5% glucose and insulin, to maintain blood glucose at 5-8 mmol/l |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| plasma exchange | Procedure | see arm description |
| |
| conservative treatment |
| Measure | Description | Time Frame |
|---|---|---|
| decrease in triglycerides | as % of starting value | within first 24 h after admission |
| Measure | Description | Time Frame |
|---|---|---|
| time until triglycerides drop to <10 mmol/l | expressed in days | by the end of hospital stay, up to 100 days |
| highest C-reactive protein (CRP) | by the end of hospital stay, up to 100 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jakob Gubensek, MD, PhD | University Medical Centre Ljubljana | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medical Centre Ljubljana, Ljubljana, Slovenia | Ljubljana | 1000 | Slovenia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35492338 | Result | Gubensek J, Andonova M, Jerman A, Persic V, Vajdic-Trampuz B, Zupunski-Cede A, Sever N, Plut S. Comparable Triglyceride Reduction With Plasma Exchange and Insulin in Acute Pancreatitis - A Randomized Trial. Front Med (Lausanne). 2022 Apr 12;9:870067. doi: 10.3389/fmed.2022.870067. eCollection 2022. |
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| ID | Term |
|---|---|
| D010195 | Pancreatitis |
| D015228 | Hypertriglyceridemia |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
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| ID | Term |
|---|---|
| D010951 | Plasma Exchange |
| D000072700 | Conservative Treatment |
| D005947 | Glucose |
| D007328 | Insulin |
| ID | Term |
|---|---|
| D001803 | Blood Transfusion |
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
| D010956 | Plasmapheresis |
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| Drug |
see arm description |
|
|
| % of patients with severe pancreatitis | by the end of hospital stay, up to 100 days |
| D052439 |
| Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D001781 |
| Blood Component Removal |
| D016060 | Sorption Detoxification |
| D005112 | Extracorporeal Circulation |
| D013514 | Surgical Procedures, Operative |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D011384 | Proinsulin |
| D061385 | Insulins |
| D010187 | Pancreatic Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |