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The study investigators propose to perform a blood test before and after allograft placement in all patients receiving a cold-stored venous allografts at the University Hospital of Nîmes to study the occurrence of FVFA-related ASD in these patients.
The aim of this work is to characterize a possible immune reaction generated by the implantation of venous allografts prepared according to the BIOPROTEC method. In case of a proven immune reaction, the study will allow a modification of our current attitude and to exclude patients potentially eligible for renal transplantation at the time of venous allograft placement, or to perform in these patients an allo-compatibility test with the venous allograft preoperatively and thus protect these patients from an increased risk of subsequent organ transplant rejection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with venous allograft |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood test | Other | Collection of blood samples at 1 and 6 months for HLA typing for donor and recipient antibodies |
|
| Measure | Description | Time Frame |
|---|---|---|
| Presence of donor specific antibodies after venous allograft | Presence/absence of donner anti-HLA antibodies in patient blood, detected using Luminex assay | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Allograft anomalies linked to allograft rejection | Inflammation, thrombosis, aneurysms progression | 1 month |
| Allograft anomalies linked to allograft rejection | Inflammation, thrombosis, aneurysms progression |
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Inclusion Criteria:
Exclusion Criteria:
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Patients receiving a scheduled venous allograft within the CHU of Nîmes for an arterial bypass in the lower limb or an arteriovenous bypass in the upper limb within the framework of the creation of arteriovenous fistulas in dialysis patients, in the absence of available autologous venous material.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elsa Faure | Contact | 04.66.68.39.30 | elsa.faure@chu-nimes.fr |
| Name | Affiliation | Role |
|---|---|---|
| Elsa Faure | CHU Nimes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nîmes | Recruiting | Nîmes | France |
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| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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serum, cell pellets, venous tissue
| 6 month |