Nasal packing is required after endoscopic pituitary adenoma resection. The patient can only breathe through the mouth. The blood and secretion in the nasal cavity may be inhaled into the trachea after the operation. GH-secreting pituitary adenoma causes pharyngeal soft tissue and tongue hypertrophy. These conditions increase the risk of respiratory obstruction and hypoxemia during anesthesia recovery. Propofol total intravenous anesthesia has a rapid effect and a low incidence of nausea and vomiting. Patients anesthetized with desflurane recover quickly is conducive to early recovery of respiratory function and orientation. This study intends to compare the effects of desflurane and propofol on the quality of anesthesia recovery period in patients undergoing endonasal endoscopic pituitary adenoma resection and to provide clinical evidence for the use of desflurane in neurosurgical anesthesia.

Inclusion Criteria:

• 18-65 years;
• Elective endoscopic transsphenoidal resection of pituitary adenomas;
• ASA status I-III;
• Informed consent signed by patients.

Exclusion Criteria:

• emergency surgery;
• complicated with cerebrovascular disease;
• complicated with pulmonary disease, oxygen saturation below 95% without oxygen;
• expected to retain endotracheal intubation;
• preoperative disturbance of consciousness was not compatible with assessment;
• complicated with primary hypothyroidism;
• previous history of cervical surgery, burns, and radiotherapy;
• BMI >30kg/m2;
• invasive pituitary adenoma with Knosp grade 4.