Comparison of Pesticide and Pharmaceutical Contaminants Levels in Placenta and Cord Blood Samples of Pregnant Women With Fetal Growth Retardation and Healthy Pregnant Women

Comparison of Pesticide and Pharmaceutical Contaminants Levels in Placenta and Cord Blood Samples of Pregnant Women With Fetal Growth Retardation and Healthy Pregnant Women

Aim: In this study, pesticide and pharmaceutical contaminants levels in the placenta and cord blood of pregnant women with fetal growth retardation and healthy pregnant women will be compared in placenta and cord blood samples after delivery.

The study will be conducted with a total of 40 pregnant women, 20 of whom are in the control groups and those with FGR diagnoses. Cases in both groups will be matched in terms of demographic information. Demographic information (including socioeconomic status, educational level, region of residence), ultrasound and Doppler examination results, newborn weight at birth, APGAR score, gender, mode of delivery, whether there is a need for neonatal intensive care or not will be recorded.

Inclusion Criteria:

• Between the ages of 18-40 years
• Gestational age between 320/7 - 396/7 weeks
• Singleton pregnancy
• For the FGR group: estimated fetal weight <10th percentile
• For the control group: being healthy pregnant
• Intact amniotic membrane

Exclusion Criteria:

• Multiple pregnancies
• Cardiovascular disease
• Chronic hypertension
• Autoimmune disease
• Intrahepatic cholestasis of pregnancy
• Preeclampsia-eclampsia
• Sepsis
• Placenta accreta spectrum
• Abnormalities of placenta
• The chromosomal or congenital structural anomaly of the fetus
• Smoking
• BMI >30 kg/m2