Exploration of Cluster Headache in a PET-MRI Study

Exploration of the 5-HT1A Receptor in Cluster Headache : a PET-MRI Study Using the PET Radiopharmaceutical [18F]F13640

Observational study in PET-MRI using the 5-HT1A agonist PET radiotracer [18F]F13640.

Inclusion Criteria:

• Male
• Age between 20 to 45 years old
• Weight between 50 to 90 kg
• No psychiatric or neurologic pathological history
• No cranial trauma history with loss of consciousness
• No juridical protection
• Free and informed consent
• Affiliated with a social security scheme or similar

Exclusion Criteria:

• Subject with present or past dependence on alcohol or any other addictive substance according to the DSM-IV-TR criteria, with the exception of nicotine, caffeine and cannabis
• Subject already participating in another biomedical research project or having participated for less than a year in a study using ionizing radiation
• Subject with a contraindication to MRI exams
• Subject with a contraindication to PET scans using [18F] F13640: hypersensitivity to the active substance or to one of the excipients (sodium chloride)
• Subject with a contraindication to sumatriptan
• Patients with an active infectious disease or associated serious and progressive medical pathology
• Subjects with an inability to understand or carry out the study (language barrier, obvious lack of motivation, etc...) as judged by the investigator
• Patient having exceeded the annual amount of compensation authorized for participation in research protocols.