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| ID | Type | Description | Link |
|---|---|---|---|
| 2017-002722-21 | EudraCT Number |
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This clinical assay is designed to validate that [18F]F13640 as a radiotracer of 5-HT1A functional receptors. A first group of healthy subjects underwent a PET scan with arterial blood sampling to determine the kinetic model of the tracer. A second group of healthy subjects underwent a classical test-retest study (i.e two distant PET scans) to determine the reproducibility of measures.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Input function group | Experimental | Each subject underwent a 90 min acquisition PET scan with concomitant arterial blood sampling |
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| Test-retest group | Experimental | Each subject underwent 2 PET scans distant from 1 to 3 weeks |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| [18F]F13640 | Drug | Radiotracer injection and PET scan acquisition of 90 min: *150 Mbq + 1 MBq/Kg of [18F]F13640 at t=0 min Arterial Blood Sampling during the 90min acquisition |
| Measure | Description | Time Frame |
|---|---|---|
| Binding potentials | Binding potentials are calculated using compartimental modelling techniques. | 180 minutes |
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Inclusion Criteria:
Exclusion Criteria:
Subjects with neurologic or psychiatric disease including all substance addictions
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| Name | Affiliation | Role |
|---|---|---|
| Scheiber Christian | Hospices Civils de Lyon | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospices Civils de Lyon | Bron | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31414208 | Result | Colom M, Costes N, Redoute J, Dailler F, Gobert F, Le Bars D, Billard T, Newman-Tancredi A, Zimmer L. 18F-F13640 PET imaging of functional receptors in humans. Eur J Nucl Med Mol Imaging. 2020 Jan;47(1):220-221. doi: 10.1007/s00259-019-04473-7. Epub 2019 Aug 14. No abstract available. |
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| [18F]F13640 | Drug | 2 Radiotracer injections and PET scan acquisition of 90 min distant from 1 to 3 weeks: For each exam: 150 MBq + 1 MBq/kg of [18F]F13640 at t=0 min |
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