[18F]-F13640 as a New Brain Radiopharmaceutical

First-in-man Study of [18F]-F13640, a PET Radiopharmaceutical for Functional 5-HT1A Receptor Imaging

This clinical assay is designed to validate that [18F]F13640 as a radiotracer of 5-HT1A functional receptors. A first group of healthy subjects underwent a PET scan with arterial blood sampling to determine the kinetic model of the tracer. A second group of healthy subjects underwent a classical test-retest study (i.e two distant PET scans) to determine the reproducibility of measures.

Inclusion Criteria:

• Healthy Subjects
• Weight between 50 kg and 90 kg
• Affiliated to a social security or similar scheme
• Not subject to any legal protection measures

Exclusion Criteria:

Subjects with neurologic or psychiatric disease including all substance addictions

• Daily smokers
• Active infectious disease
• MRI contraindications
• PET contraindications determined with FDG injection
• Subjects deprived of their liberty by judicial or administrative decision
• Subjects unable to sign written consent for participation in the study.
• Severe and progressive medical pathology
• Volunteer who has exceeded the annual amount of compensation authorized for participation in research protocols