Large Macular Hole Closure Rate With Amniotic Membrane Graft With and Without Limitorrhexis

Comparison of Macular Hole Closure Rate in Patients With Poor Prognosis Clinical Features Treated With Amniotic Membrane Graft With and Without Limitorrhexis

Patients with idiopathic macular holes (MHs) postoperative closure rates for large MHs (diameter > 550 μm) are disappointing and often require a second intervention, different techniques have been described with very variable success rates in different published studies, an efficient technique with good functional outcome has not been found.

Interventional study in large macular holes (diameter > 550 μm) using an amniotic membrane with and without internal limiting membrane peeling.

Inclusion Criteria:

• Not myopic patients (<6 Dioptre or <26 mm)
• Large macular hole >550 μm
• > 6 months symptoms
• Signing informed consent

Exclusion Criteria:

• Patients with other ocular disease (diabetic retinopathy, glaucoma, uveitis, ocular tumors, etc)
• Using systemic drugs that are toxic for the optic nerve or retina (chloroquine, hydroxychloroquine, tamoxifen, ethambutol, etc)
• Patients with ocular surgery