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| Name | Class |
|---|---|
| Hospital Clinic of Barcelona | OTHER |
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Muscular Dystrophies (MD) are a heterogeneous group of diseases characterised by muscle wasting that lead to progressive loss of function. Although exercise training has been traditionally neglected to these patients due to concerns regarding muscle damage, research has shown that exercise therapy is safe and tolerable in this population and can lead to potential gains in endurance and muscle strength, as well as other patient-reported outcomes such as health-related quality of life.Therefore, in this study, the investigators aim to examine the feasibility, tolerability and safety as well as the effects of a 12-week, exercise-training program in patients with MD on functional capacity, muscle strength, and health-related quality of life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise Training | Experimental | This group will engage in a 12-week exercise training program |
|
| Control group | No Intervention | Usual care. Patients in this group will be offered the same program at the end of the study |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise Training | Behavioral | 12-week exercise training program including a combination of endurance and resistance training for 45 minutes, twice a week. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Timed Up and Go | Time consumed by the patient to raise from a chair, walk 3 meters, turn 180º, walk 3 metres back and sit down on the chair | 1 week post-intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Short Physical Performance Battery | Score in this test is derived from three assessments: balance, gait speed and lower limb muscle performance | 1 week post-intervention |
| Upper Body Muscle Strength |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Clinic de Barcelona | Barcelona | Barcelona | 08036 | Spain |
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| ID | Term |
|---|---|
| D009136 | Muscular Dystrophies |
| ID | Term |
|---|---|
| D020966 | Muscular Disorders, Atrophic |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009468 | Neuromuscular Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Post-training assessments will be conducted by a blinded assessor
Muscle strength of the biceps brachii will be assessed with a hand-held dynamometer
| 1 week post-intervention |
| Lower Body Muscle Strength | Muscle strength of the quadriceps will be assessed with a hand-held dynamometer | 1 week post-intervention |
| Handgrip Strength | Handgrip strength will be assessed with a hydraulic dynamometer. | 1 week post-intervention |
| Health-Related Quality of Life | HRQoL will be measured with the Short-Form Health Survey (SF-12). The score of the scale goes from 0 - 100, with higher scores representing better health-related quality of life. | 1 week post-intervention |
| Body Weight | Body weight (kg) | 1 week post-intervention |
| Body Mass Index | Body weight and height will be combined to report the results on body mass index (kg/m2) | 1 week post-intervention |
| Percentage of fat-free mass | Percentage of fat-free mass will be obtained through bio-impedance analysis | 1 week post-intervention |
| Percentage of fat mass | Percentage of fat mass will be obtained through bio-impedance analysis | 1 week post-intervention |
| Fatigue | Fatigue will be quantified with the Brief Fatigue Inventory. The scale has 9 items with a maximal score of 10 points. Higher scores represent heavier fatigue. | 1 week post-intervention |
| Respiratory Muscle Strength | Maximal Inspiratory and Expiratory Muscle Strength will be measured according to international guidelines (ATS/ERS) with a MicroRPM. | 1 week post-intervention |
| Physical Activity Levels | Accelerometry-assessment of physical activity will be measured in terms of steps per day and minutes spent in light, moderate and vigorous physical activity | 1 week post-intervention |
| D009422 | Nervous System Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |