Effects of a Multiple Component Training Program on Muscles in Adults With Myotonic Dystrophy Type 1

Effects of a Multiple Component Training Program on Muscles, Maximal Muscle Strength, Endurance and Functional Performance in Adults With Myotonic Dystrophy Type 1: A Pilot Study

A strength and endurance training program was conducted in adults with myotonic dystrophy type 1 (DM1). Participants underwent a 12-week/18-session supervised training program consisted of 6 exercises: elbow flexion/extension, shoulder horizontal adduction, leg press, and knee flexion/extension. To offer a complete training program aimed at improving function it was divided: the first 6 weeks were dedicated to strength-training, whereas the following weeks focused on endurance-training. To evaluate the effects of the training program, participants completed maximal strength, endurance and functional evaluations. Volunteers could also add a muscle biopsy at the beginning and the end of the program to evaluate physiological parameters.

Inclusion Criteria:

• Adults with DM1
• Walk without technical aid
• Muscle impairment rating scale (MIRS) of 3 or 4

Exclusion Criteria:

• Severe musculoskeletal disorders
• Any medical contraindication to physical exercise
• Any medical contraindication to muscle biopsies for the biopsy volunteers