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| Name | Class |
|---|---|
| Fondation du Grand défi Pierre Lavoie | UNKNOWN |
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A strength and endurance training program was conducted in adults with myotonic dystrophy type 1 (DM1). Participants underwent a 12-week/18-session supervised training program consisted of 6 exercises: elbow flexion/extension, shoulder horizontal adduction, leg press, and knee flexion/extension. To offer a complete training program aimed at improving function it was divided: the first 6 weeks were dedicated to strength-training, whereas the following weeks focused on endurance-training. To evaluate the effects of the training program, participants completed maximal strength, endurance and functional evaluations. Volunteers could also add a muscle biopsy at the beginning and the end of the program to evaluate physiological parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Training program | Experimental | 12-week strength and endurance training program |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Training program | Other | 12-week, 18-session training program. To offer a complete training program aimed at improving function it was divided : the first 6 weeks were dedicated to strength-training (2 sets of 6 repetitions at 80% of 1-RM), whereas the following weeks focused on endurance-training (1 set of 25 repetitions at 40% of 1-RM). |
| Measure | Description | Time Frame |
|---|---|---|
| Change in maximal muscle strength in the knee extensors measured by quantified muscle testing | Changes in knee extensor maximal muscle strength evaluated by quantified muscle testing with a handheld dynamometer. | Before and after the 12-week training program |
| Measure | Description | Time Frame |
|---|---|---|
| Change in 6 minute walking test disance | Walking endurance change measured by the 6 minute walking test distance. | Before and after the 12-week training program |
| Changes in functional capacity measured by the UQAM-YMCA test |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Cynthia Gagnon, Ph.D. | Université de Sherbrooke | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Groupe de recherche interdisciplinaire sur les maladies neuromusculaires | Saguenay | Quebec | G7X 7X2 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31429798 | Derived | Roussel MP, Morin M, Girardin M, Fortin AM, Leone M, Mathieu J, Gagnon C, Duchesne E. Training program-induced skeletal muscle adaptations in two men with myotonic dystrophy type 1. BMC Res Notes. 2019 Aug 20;12(1):526. doi: 10.1186/s13104-019-4554-z. |
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| ID | Term |
|---|---|
| D009223 | Myotonic Dystrophy |
| ID | Term |
|---|---|
| D009136 | Muscular Dystrophies |
| D020966 | Muscular Disorders, Atrophic |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
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|
Functional capacity evaluated by 18 functional tests
| Before and after the 12-week training program |
| Changes in sprint capacity measured by the Running-base anaerobic sprint test | Sprint capacity changes measured by the running-base anaerobic sprint test | Before and after the 12-week training program |
| Changes in fatigue measured by the Fatigue severity scale | Fatigue questionnaire: 9-item questionnaire rated on a scale from 1 to 7 for each item. A score a higher score means more fatigue. | Before and after the 12-week training program |
| Changes in daytime sleepiness measured by the Daytime sleepiness scale (Epworth Sleepiness Scale) | 8-item questionnaire, rated on a scale from 0 to 3 for each item, the higher the score, the more the patient has daytime sleepiness. | Before and after the 12-week training program |
| Changes in stumbles and falls measured by the Falls efficacy scale | 10-item questionnaire about stumbles and falls. All items are rated on a 10-point scale. A higher score means a higher fear of falling. A score over 70 means a significant fear of falling. | Before and after the 12-week training program |
| Changes in quality of life measured by the 36-Item Short Form Survey (SF-36) | 36-item quality of life questionnaire. The final score is calculated on a total of 100 where the lower the score, the more disability. A score of 100 means no disability. | Before and after the 12-week training program |
| Changes in life habits measured by questionnaire | Life habits questionnaire Assessment of life habits is a 77-item questionnaire with a scale from 0 to 9 for each item. A higher score means no disability and a low score means more disability. | Before and after the 12-week training program |
| Changes in muscle biopsy-muscle fiber size | To assess changes in muscle fiber size | Before and after the 12-week training program for volunteers |
| Changes in muscle biopsy-muscle fiber typing | To assess changes in muscle fiber typing | Before and after the 12-week training program for volunteers |
| Changes in muscle biopsy-proportion of centrally nuclated fibers | To assess changes in muscle centrally nucleated fibers proportion | Before and after the 12-week training program for volunteers |
| Changes in muscle biopsy-leucocyte infiltration | To assess changes in muscle fiber leucocyte infiltration | Before and after the 12-week training program for volunteers |
| D020967 | Myotonic Disorders |
| D020271 | Heredodegenerative Disorders, Nervous System |
| D019636 | Neurodegenerative Diseases |
| D009422 | Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |