Comparing Three Different Doses of Intrathecal Ketamine

Analgesic Effects of Three Different Doses of Intrathecal Ketamine as an Adjuvant to Intrathecal Bupivacaine in Patients Undergoing Knee Arthroscopy. A Randomized Prospective Double-blinded Study

The aim of this study is to compare the postoperative analgesic effect of three different doses of intrathecal ketamine as an adjuvant to bupivacaine in patients undergoing knee arthroscopy.

A meta-analysis of adult human randomized controlled studies that compared single dose perioperative intrathecal ketamine plus intrathecal bupivacaine to bupivacaine alone in spinal anesthesia suggests that there is a benefit to using intrathecal ketamine as an adjunct to bupivacaine in multimodal analgesia. However, there are still knowledge and experience gaps regarding neuraxial ketamine dosing in this regard.

Aim of the study:

The aim of this study is to compare the postoperative analgesic effect of three different doses of intrathecal ketamine as an adjuvant to bupivacaine in patients undergoing knee arthroscopy.

Inclusion Criteria:

• Age: 18-70 years.
• BMI: 20-30 kg.m2
• Sex: both males and females.
• ASA physical status: I-III.
• Operation: knee arthroscopy.

Exclusion Criteria:

• Patient's refusal to participate in the study.
• Aged less than 18 years,
• known allergy to L.A.,
• Coagulopathy or thrombocytopenia,
• height less than 150 cm, morbidly obese infection at the site of injection.
• Chronic pain syndromes,
• pregnant woman
• Patients on regular use of analgesic or who received analgesic 24 h before surgery.