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twin pregnant women requesting cesarean section, the effectiveness and safety of temporary uterine packing coupled with topical tranexamic acid as an adjuvant for decreasing blood loss during delivery were compared to placebo.
The most common cause of postpartum hemorrhage (PPH) is uterine atony, which accounts for up to 80% of PPH occurrences. PPH is the main cause of maternal morbidity and mortality, accounting for up to 28% of all maternal deaths globally. As a result, generating a fast and efficient uterine contraction after birth is critical. Obesity, White or Hispanic race/ethnicity, polyhydramnios, preeclampsia, anemia, and chorioamnionitis, as well as a twin pregnancy, are all risk factors for uterine atony.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Topical tranexamic acid | Experimental | temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid |
|
| normal saline | Placebo Comparator | temporary uterine packing with gauze of the dimensions soaked with 2 gm placebo to tranexamic diluted in 60ml saline acid |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Topical tranexamic acid | Drug | temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid |
|
| Measure | Description | Time Frame |
|---|---|---|
| intraoperative blood loss | measurement the intraoperative blood loss by direct and gravimetric methods | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative blood loss | measurement the intraoperative blood loss by direct and gravimetric methods | 12 hours |
| need of blood transfusion | number of unites of blood transfusion |
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Inclusion Criteria:
Exclusion Criteria:
Women With Twin Pregnancy Undergoing Cesarean Section
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| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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a double-blind randomized controlled study
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a double-blind randomized controlled study
|
| normal saline | Other | temporary uterine packing with gauze of the dimensions soaked with 2 gm placebo to tranexamic diluted in 60ml saline acid |
|
|
| 24 hours |
| need of uterotonic | misoprostol, oxytocin etc | 24 hours |
| change in hemoglobin | change in hemoglobin | 24 hours |
| D000077324 |
| Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |