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In hypertensive women having an elective cesarean section, the effectiveness and safety of temporary uterine packing coupled with topical tranexamic acid as an adjuvant for decreasing blood loss during delivery were compared to placebo.
patients were allocated to one of two groups after induction of anesthesia. they received temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid or placebo
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Topical tranexamic acid | Experimental | temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid or placebo |
|
| normal saline | Placebo Comparator | temporary uterine packing with gauze of the dimensions soaked with 2 gm placebo to tranexamic diluted in 60ml saline acid |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Topical tranexamic acid | Drug | temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid |
|
| Measure | Description | Time Frame |
|---|---|---|
| intraoperative blood loss | measures the intraoperative blood loss by direct and gravimetric methods | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| need of blood transfusion | number of unites of blood transfusion | 12 hours |
| need of uterotonic | misoprostol, oxytocin etc | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
hypertensive women undergoing elective cesarean section
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| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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a double-blinded randomized controlled trial
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a double-blinded randomized controlled trial
|
| : normal saline | Other | temporary uterine packing with gauze of the dimensions soaked with placebo to 2 gm tranexamic diluted in 60ml saline acid |
|
|
| change in hemoglobin | change in hemoglobin | 24 hours |
| D000077324 |
| Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |