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LIVER PAM
A randomized, controled, open and unicentric trial comparing high (MAP 85-90 mmHg) and low (65-70 mmHg) target of mean arterial pressure in the first 24 hours after liver transplantation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hihg Target Mean Arterial Pressure | Experimental | Target of mean arterial pressure of 85-90 mmHg in ther first 24h after liver transplant. |
|
| Low Target Mean Arterial Pressure | Active Comparator | Target of mean arterial pressure of 65-70 mmHg in ther first 24h after liver transplant. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Usual Care + High Target of Mean Arterial Pressure | Other | Targeting the weaning of vasopressors to a mean arterial pressure of 85-90mmHg in the first 24h after liver trasnplant. |
|
| Measure | Description | Time Frame |
|---|---|---|
| incidence of Acute Kidney Disfunction | Incidence of acute kidney Disfunction according to kdigo criteria. | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | percentage of mortality in 28 days | 28 days |
| re-transplant | percentage of re-transplant in 28 days | 28 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Das ClÃnicas Da Faculdade de Medicina Da Universidade de São Paulo | São Paulo | São Paulo | 05403-000 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37712725 | Derived | Pedro RAM, Scharranch BC, Araujo LO, Brandao LS, Andrade LDC, Andraus W, D'Albuquerque LAC, Malbouisson LMS. High versus low mean arterial pressure target in liver transplant patients. An open, controlled, single-center, randomized clinical trial - Protocol and methods (LIVER-PAM). Crit Care Sci. 2023 Mar 1;35(1):11-18. doi: 10.5935/2965-2774.20230336-en. |
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| Usual Care | Other | Targeting the weaning of vasopressors to a mean arterial pressure of 65-70mmHg in the first 24h after liver trasnplant. |
|
| Lenght of Hospitay Stay | LOS in 28 days | 28 days |
| Lenght of ICU Stay | ICU LOS in 28 days | 28 days |
| Days alive and out of hospital in 28 days | Number of days alive and out of hospital in 28 days | 28 days |
| Substitutive Renal Therapy | percentage of TSR in 7 days | 7 days |
| Days Alive and free of renal disfunction | Days Alive and free of renal disfunction in 28 days | 28 days |
| Acute kidney insufficiency according to Urinary NGAL on d0 and D2 | Percentage of renal disfunction according to NGAL criteria on D0 and D2 | 0d and 2d |
| MAKE28 | Major Kidney Events ( Death, persistent acute kidney disfunction or need of RRT in 28 days) | 28 days |
| Liver graft primary disfunction ( Initial Poor Function) | percentage of Initial Poor Function in 7 days | 7 days |
| Liver graft primary disfunction (primary nonfunction) | percentage of primary nonfunction in 10 days | 10 days |
| Surgical site infection | percentage of SSI in 28 days | 28 days |
| Need of Transfusion | percentage of Transfusion requirement in 7 days | 7 days |
| Postoperative Major bleeding in 7 days | Bleeding that requires 2 units of blood transfusion in a single day or the need of a reoperation due to bleeding in the first 24 hours after surgery. | 7 days |
| Incidence of Arrythmia requiring clinical treatment | percentage of Arrhythmia requiring treatment in 7 days | 7 days |