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In the frame of Si-CART study, blood will be collected from patients treated with CAR-T cells: before (at Day (D)-6 and D0 before cells injection), post infusion at D3, D5,D7, D9, D11, D14, D18, D 21, Month (M) 2 and M12 post injection.
A cerebrospinal fluid sample will also be collected if a Cerebrospinal Fluid Analysis Lumbar puncture is performed
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient treated with CAR-T cells | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sample collection | Other | Blood samples collection: at Day (D)-6 and D0 before CAR-T cells injection, post injection at Day (D)3, D5,D7, D9, D11, D14, D18, D 21, Month 2 and Month 12 post injection. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between serum markers and adverse events at 1 year of the CAR-T cells infusion | Serum concentration of cytokines in relation to adverse events | 1 year after T cells infusion |
| Measure | Description | Time Frame |
|---|---|---|
| CAR-T cells rate from infusion to one year after CAR-T cells infusion | Flow cytometry | From CAR-T cells infusion to one year |
| Number of participants with a relapse | Relapse rate from CAR-T cells infusion to one year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dominique GENRE, MD | Contact | +33491223778 | drci.up@ipc.unicancer.fr | |
| Jihane PAKRADOUNI, Pharm PhD | Contact | +33491223778 | pakradounij@ipc.unicancer.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut Paoli-Calmettes | Marseille | 13273 | France |
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| ID | Term |
|---|---|
| D019337 | Hematologic Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| From CAR-T cells infusion to one year |
| Number of participants with a cytokine release syndrome | Cytokine release syndrome from CAR-T cells infusion to one year | From CAR-T cells infusion to one year |