Immunological Profile for Patients Treated With CAR-T Cells

Immunological Profile for Patients Treated With CAR-T Cells

In the frame of Si-CART study, blood will be collected from patients treated with CAR-T cells: before (at Day (D)-6 and D0 before cells injection), post infusion at D3, D5,D7, D9, D11, D14, D18, D 21, Month (M) 2 and M12 post injection.

A cerebrospinal fluid sample will also be collected if a Cerebrospinal Fluid Analysis Lumbar puncture is performed

Inclusion Criteria:

• Age ≥ 18 years
• Planned injection of CAR-T cells within the scope of marketing authorization
• Signed informed consent
• French social security affiliation

Exclusion Criteria:

• Pregnant women, or women of childbearing potential (without medically acceptable contraception) or breastfeeding women.
• Patient in emergency situation, adult under legal protection (patient placed under tutorship, curatorship, or judicial protection) or unable to give his consent
• Impossibility to comply with trial medical follow-up for geographic, social or psychological reasons