Effect of Ibuprofen Sustained Release on Intraoperative and Postoperative Pain in Mandibular Molars

The Effect of Ibuprofen Sustained Release Oral Premedication on Intraoperative and Postoperative Pain After Single-visit Root Canal Treatment of Mandibular Molars With Symptomatic Irreversible Pulpitis and Apical Periodontitis

The study is conducted to evaluate the effect of Ibuprofen sustained release premedication on the success of buccal infiltration anaesthesia, intaroperative pain and post operative pain in mandibular molars with symptomatic irreversible pulpitis and apical periodontitis

Inclusion Criteria:

1. Systemically healthy patients (ASA I or II).

2. Patients with Mandibular molar teeth diagnosed with:

   • Pre-operative sharp pain marked on VAS scale by reading not less than 6.
   • Vital exaggerated response of pulp tissue to cold pulp tester (ethyl chloride spray) and electric pulp tester.
   • Normal periapical radiographic appearance or slight widening in lamina dura.
   • Positive response and pain provoked by percussion.

Exclusion Criteria:

1. Allergy to Ibuprofen

2. Medically compromised patients having significant systemic disorders. (ASA III or IV).

3. History of intolerance to NSAIDS.

4. Patients with two or more adjacent teeth requiring endodontic treatment.

5. Pregnant or nursing females.

6. Teeth that have:

   • Periodontal affection (with pocket depth greater than 5mm, associated with swelling or fistulous tract, or greater than grade I mobility)
   • No possible restorability.