Premedication on Post-endodontic Pain

Effect of Premedication on Post-endodontic Pain in Patients With Symptomatic Irreversible Pulpitis, a Triple-blinded Randomized Control Trial

The goal of this clinical trial is to compare the efficacy of preoperative administration of alpha-chemo-trypsin, ibuprofen, and acetaminophen in managing post-endodontic pain in patients with symptomatic irreversible pulpitis. The main question it aims to answer is:

What is the efficacy of preoperative administration of alpha-chemo-trypsin, ibuprofen, and acetaminophen in managing post-endodontic pain in patients with symptomatic irreversible pulpitis? Participants will undergo root canal treatment after premedication. Researchers will compare [alpha-chemo-trypsin, ibuprofen, and acetaminophen] to see the intensity of post-endodontic pain.

Inclusion Criteria:

• Eligibility for root canal treatment Patients diagnosed with symptomatic irreversible pulpitis with normal apical tissue in mandibular molars

Exclusion Criteria:

• • Patient under any medication or analgesic intake for pain management.

  • Patients with any systemic health issues
  • Patient allergies to trypsin-chymotrypsin, ibuprofen, and paracetamol
  • Pregnancy.
  • Non-restorable teeth.
  • Immature roots.
  • Calcifications.
  • Resorptions.