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The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients with liver cirrhosis after implantation of transjugular intrahepatic portosystemic shunt (TIPS).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with cirrhosis | Patients with cirrhosis and transjugular intrahepatic portosystemic shunt implantation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transjugular intrahepatic portosystemic shunt implantation | Procedure | Transjugular intrahepatic portosystemic shunt is an artificial channel within the liver that establishes communication between the inflow portal vein and the outflow hepatic vein. It is used to treat portal hypertension (e.g., in liver cirrhosis) |
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial T1 relaxation time | T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in [ms]. | Change after 1 year of transjugular intrahepatic portosystemic shunt insertion. |
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial T2 relaxation time | T2 relaxation times will be obtained to asses myocardial edema. T2 maps will be analyzed using a segmental approach by region of interest analysis. T2 relaxation times are given in [ms]. | Change after 1 year of transjugular intrahepatic portosystemic shunt insertion. |
| Myocardial ECV |
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Inclusion criteria:
Exclusion criteria:
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Primary care clinic (Department of Internal Medicine I, University Hospital Bonn, Germany)
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Bonn, Clinic for Diagnostic and Interventional Radiology | Bonn | North Rhine-Westphalia | 53127 | Germany | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32808886 | Background | Isaak A, Praktiknjo M, Jansen C, Faron A, Sprinkart AM, Pieper CC, Chang J, Fimmers R, Meyer C, Dabir D, Thomas D, Trebicka J, Attenberger U, Kuetting D, Luetkens JA. Myocardial Fibrosis and Inflammation in Liver Cirrhosis: MRI Study of the Liver-Heart Axis. Radiology. 2020 Oct;297(1):51-61. doi: 10.1148/radiol.2020201057. Epub 2020 Aug 18. |
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| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| D009202 | Cardiomyopathies |
| D006975 | Hypertension, Portal |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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|
| Magnetic resonance imaging | Diagnostic Test | Multiparametric cardiac and hepatic magnetic resonance imaging |
|
Myocardial extracellular volume will be obtained to asses extracellular space/myocardial fibrosis. ECV values will be calculated using a segmental approach by region of interest analysis of native and contrast-enhanced T1 relaxation maps. ECV values are given in [%]. |
| Change after 1 year of transjugular intrahepatic portosystemic shunt insertion. |
| University Hospital Bonn, Medical Clinic and Polyclinic I |
| Bonn |
| North Rhine-Westphalia |
| 53127 |
| Germany |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |