Perfusion Assessment Using BOLD MRI and PBV in Endovascular Treatment of Peripheral Arterial Occlusive Disease

A Prospective Study: Perfusion Assessment Using Blood Oxygen Level Dependent Functional Magnetic Resonance Angiographic Imaging and Parenchymal Blood Volume Imaging in Endovascular Treatment of Peripheral Arterial Occlusive Disease

Current assessment of lower limb ischemia cannot reflect the location and degree of ischemia. Tissue perfusion assessment was used in the diagnosis and treatment of lower limb ischemia in this project, and the quantitative evaluation of ischemia degree was realized by using its advantages of quantitative analysis and perfusion imaging.

Inclusion Criteria:

• Subject has been diagnosed as PAOD by symptom and imaging;
• Subject intends to take endovascular treatment in PUMCH;
• Subjects without heavy stenosis in infrapopliteal artery (stenosis<30%), or with short length lesion(length≤5cm, stenosis≥30%);
• Age > 35 and < 80;
• Subject has been informed the study and has signed informed consent;

Exclusion Criteria:

• Subject with MRI contraindications or allergic to iodinated contrast medium;
• Subject underwent intervention therapy or angioplasty in target vessel within the last 3 months;
• Subject after stent implantation in superficial femoral artery;
• Subject with severe heart dysfunction, renal dysfunction, or cancer;