The main objective of this study is to assess the ovarian reserve of CF patients via measurement of AMH and AFC. Secondly, we aim to correlate between the ovarian reserve and demographic and clinical characteristics of these patients.

Outcomes measured will be levels of AMH and AFC, as compared to standard means in the general population. There is no need for a control group in this study since the standardized means of AMH and AFC in the general population are a more accurate comparable measure, which is based on data collected from large-scale populations, and thus accounts for confounding age factor in a more complete manner than can be obtained via a control group (Almog et al., 2011, La Marca et al., 2012, Penzias et al., 2020).

Inclusion Criteria:

• Female patients diagnosed with CF according to genetic testing.
• Age 18-45 years old.
• Routinely attended the CF Center at Hadassah Medical Center.

Exclusion Criteria:

• Refusal to participate in the study.
• Age under 18 or above 45.
• Use of hormonal contraceptives (for the purpose of AFC).

Female CF patients seen regularly in the Hadassah Mt. Scopus CF Center, aged 18-45 years old, who regularly attended the clinic, and from whom demographic and clinical parameters are available.