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The main goal of the study was to characterize the morbidity, immunological, microbiolical and clinical phenotypes of patients with treated- resistance to Helicobacter pylori (HP) infection, and the effect of triple therapy including the levofloxacin. Control groups were newly diagnosed, previously infected and never infected HP patients
See Nestegard O, et al. PLOS ONE | https://doi.org/10.1371/journal.pone.0238944 September 23, 2020
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Helicobacter pylori resistance | Patients with treatment resistance to Helicobacter pylori treatment registered at GI-unites from 1990-2012 and included from 2010 to 2012. These patients were treated with a triple therapy of levofloxacin, amoxicillin and proton inhibitor for 10 days |
| |
| Newly diagnosed Helicobacter pylori | Patients with newly diagnosed Helicobacter pylori infection from 2010-2012.These patients were treated with a triple therapy of clarithromycin, amoxicillin and proton inhibitor for 10 days |
| |
| Previously eradicated Helicobacter pylori infection | Patients with previously Helicobacter pylori infection included from 2010-2012. | ||
| Never Helicobacter pylori infection | Patients with previously Helicobacter pylori infection included from 2010-2012. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| levofloxacin, amoxicillin, clarithromycin | Drug | Triple therapy of Helicobacter pylori including two antibiotics and a proton inhibitor for 10 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Characterization of patients with chronic HP infection resistant to previous conventional triple therapy | Clinical data including endoscopy, histology, microbiological data including resistance measurements, immunological data (mucosal tranacrips), effect of triple therapy | 2010-2012 |
| Endoscopy | endoscopic description of mucosa bye endoscopy | 2010-2012 |
| Histology | Histological characterizations of inflammation (Sydney) of gastric mucosa | 2010-2012 |
| Immunology | Immunological mucosal characterizations of pro- and antiinflammatory cytokine transcript (PCR) | 2010-2012 |
| HP microbiology | HP microbiology sensitivity to metronidazol, amoxicillin, clarithromycine, levofloxacin and tetracycline | 2010-2012 |
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Inclusion Criteria:
Patients referred to a GI- unite with upper GI complains and performing an upper endoscopy -
Exclusion Criteria:
Patients with severe chronic diseases and not willing to participate
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| Name | Affiliation | Role |
|---|---|---|
| Jon Florholmen | Department of Gastroenterology, Norwegian Artic University/Universiuty of Tromsø, Norway | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35442962 | Derived | Nestegard O, Moayeri B, Halvorsen FA, Tonnesen T, Sorbye SW, Paulssen E, Johnsen KM, Goll R, Florholmen JR, Melby KK. Helicobacter pylori resistance to antibiotics before and after treatment: Incidence of eradication failure. PLoS One. 2022 Apr 20;17(4):e0265322. doi: 10.1371/journal.pone.0265322. eCollection 2022. |
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| ID | Term |
|---|---|
| D064704 | Levofloxacin |
| D000658 | Amoxicillin |
| D017291 | Clarithromycin |
| ID | Term |
|---|---|
| D015242 | Ofloxacin |
| D024841 | Fluoroquinolones |
| D042462 | 4-Quinolones |
| D015363 | Quinolones |
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RNA measure of mucosal transcripts, mucosal histology, cultures including antibiotic sensitivity to HP from mucosal biopsies
| D011804 |
| Quinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D000667 | Ampicillin |
| D010400 | Penicillin G |
| D010406 | Penicillins |
| D047090 | beta-Lactams |
| D007769 | Lactams |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013457 | Sulfur Compounds |
| D004917 | Erythromycin |
| D018942 | Macrolides |
| D061065 | Polyketides |
| D007783 | Lactones |