Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Objective to investigate the protective effect of preoperative electroacupuncture on lung function in patients with mechanical ventilation for more than 2 hours under general anesthesia
Randomized parallel control study. From September 1, 2021 to December 31, 2022, patients with mechanical ventilation time more than 2 hours will be randomly divided into electroacupuncture pretreatment group and blank control group. The blood gas index, ventilator parameters and serum inflammatory factor concentration of patients will be evaluated to evaluate whether electroacupuncture has protective effect on lung function of patients with mechanical ventilation.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| electroacupuncture group | Experimental | In the electroacupuncture group, acupoints of Lieque (+), Chize (-), Sanyinjiao (-), Zusanli (+), Tanzhong (+) and Yutang (-) will be selected for electrical stimulation. Density wave will be selected, and the current intensity should be tolerated by the patients. Conventional anesthesia operation could be started after the connection of electroacupuncture, and acupuncture point stimulation was stopped 30min later. |
|
| control group | No Intervention | The patient underwent routine anesthesia without acupuncture treatment |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| electroacupuncture | Other | In the electroacupuncture group, acupoints of Lieque (+), Chize (-), Sanyinjiao (-), Zusanli (+), Tanzhong (+) and Yutang (-) will be selected for electrical stimulation. Density wave will be selected, and the current intensity should be tolerated by the patients. Conventional anesthesia operation could be started after the connection of electroacupuncture, and acupuncture point stimulation will be stopped 30min later. |
| Measure | Description | Time Frame |
|---|---|---|
| oxygenation index | record oxygenation index | Before anesthesia |
| oxygenation index | record oxygenation index | 2 hours after tracheal intubation |
| oxygenation index | record oxygenation index | 5 minutes after tracheal intubation removal |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative comfort score | Assess the quality of recovery during recovery | during anesthesia recovery period |
| sedation score (Ramsay) | Assess the quality of recovery during recovery |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lingling Ding, Doctor | Contact | +86 010 52176647 | dinglingling301@126.com | |
| Jiaqi Ning, bachelor | Contact | +86 010 52176647 | ningjiaqi95@163.com |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D055397 | Ventilator-Induced Lung Injury |
| ID | Term |
|---|---|
| D055370 | Lung Injury |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D015671 | Electroacupuncture |
| ID | Term |
|---|---|
| D003131 | Combined Modality Therapy |
| D013812 | Therapeutics |
| D015670 | Acupuncture Therapy |
| D000529 | Complementary Therapies |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| during anesthesia recovery period |
| restfulness score (DRS) | Assess the quality of recovery during recovery | during anesthesia recovery period |
| visual analogue scale (VAS) | Assess the quality of recovery during recovery | during anesthesia recovery period |
| Length of stay | Assess the quality of postoperative recovery | 1 week after discharge, the patient's length of stay will be recorded through medical record system |
| postoperative time in hospital | Assess the quality of postoperative recovery | 1 week after discharge, the patient's postoperative time in hospital will be recorded through medical record system |
| postoperative complications of major organs | Assess the quality of postoperative recovery | Major organ complications during hospitalization，assessed up to 30 days after surgery |
| mortality within 30 days | Assess the quality of postoperative recovery | mortality within 30 days will be recorded |
| Expression of IL-18 in serum | The perioperative inflammation level will be assessed | Before anesthetic induction the radial artery blood samples will be collected, and the expressions of IL-18 in serum will be detected by flow cytometry |
| Expression of IL-18 in serum | The perioperative inflammation level will be assessed | 5minutes after tracheal intubation removal the radial artery blood samples will be collected, and the expressions of IL-18 in serum will be detected by flow cytometry |
| Expression of IL-1β in serum | The perioperative inflammation level will be assessed | Before anesthetic induction the radial artery blood samples will be collected, and the expressions of IL-1β in serum will be detected by flow cytometry |
| Expression of IL-1β in serum | The perioperative inflammation level will be assessed | 5minutes after tracheal intubation removal the radial artery blood samples will be collected, and the expressions of IL-1β in serum will be detected by flow cytometry |
| Expression of IL-10 in serum | The perioperative inflammation level will be assessed | Before anesthetic induction the radial artery blood samples will be collected, and the expressions of IL-10 in serum will be detected by flow cytometry |
| Expression of IL-10 in serum | The perioperative inflammation level will be assessed | 5minutes after tracheal intubation removal the radial artery blood samples will be collected, and the expressions of IL-10 in serum will be detected by flow cytometry |
| Mean arterial pressure | Intraoperative vital signs will be recorded | Before anesthesia ,2 hours after tracheal intubation , and 5minutes after tracheal intubation removal |
| heart rate | Intraoperative vital signs will be recorded | Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal |
| BIS | Intraoperative vital signs will be recorded | Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal |
| extubation time | Intraoperative vital signs will be recorded | Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal |
| anesthesia dosage | Intraoperative vital signs will be recorded | Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal |
| D004599 |
| Electric Stimulation Therapy |
| D026741 | Physical Therapy Modalities |
| D012046 | Rehabilitation |
| D004561 | Transcutaneous Electric Nerve Stimulation |
| D000698 | Analgesia |
| D000760 | Anesthesia and Analgesia |
| D000758 | Anesthesia |