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| Name | Class |
|---|---|
| National Research Centre, Egypt | OTHER |
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Published data on sequential transfer are limited and are not consistent. Also, further research into methods of risk combination and assessment, would allow us to help our patients make better-informed decisions about whether or not to proceed with invasive diagnostic tests as the PGS. So our study aims to describe the ongoing pregnancy rate for poor responders women undergoing four different embryo transfer protocols among four arms within the study. Moreover, to describe the miscarriage rate, and the baseline characteristics for the same population. This clinical study will be conducted in compliance with the clinical study protocol and applicable regulatory requirements.
The study aims to describe the ongoing pregnancy rate for poor responders women undergoing four different embryo transfer protocols among four arms within the study. Moreover, to describe the miscarriage rate, and the baseline characteristics for the same population. This clinical study will be conducted in compliance with the clinical study protocol and applicable regulatory requirements.
This study is prospective, comparative, open label and multi-center study. The study participants' relevant medical records will be collected and reviewed after obtaining informed consent for the participants.
The study materials that will be used will include blood tests, and ultrasound. The study will involve four study arms:
Arm 1: Poor responders women undergoing frozen sequential embryo transfer on Day 3 and Day 5 Arm 2: Poor responders women undergoing sequential fresh embryo transfer on Day 3 and Day 5 Arm 3: Poor responders women undergoing sequential embryo transfer on Day 3 and Day 5 after performing PGS Arm 4: Poor responders women undergoing conventional frozen embryo transfer on Day 5
Primary and secondary key measurements will be used in the study.
The primary measures will include:
The secondary key measures will include:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm 1 | Poor responders women undergoing frozen sequential embryo transfer on Day 3 and Day 5 |
| |
| Arm 2 | Poor responders women undergoing sequential fresh embryo transfer on Day 3 and Day 5 |
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| Arm 3 | Poor responders women undergoing sequential embryo transfer on Day 3 and Day 5 after performing PGS |
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| Arm 4 | Poor responders women undergoing conventional frozen embryo transfer on Day 5 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Embryo transfer method | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| ongoing pregnancy rate for poor responders women in the four arms | Recording the following for the four arms of the study:
| Till the end of 12 weeks of gestation |
| Measure | Description | Time Frame |
|---|---|---|
| miscarriage rate for poor responders women in the four arms | Recording the following for the four arms of the study: - Occurance of abortion between week 7 and week 20 of gestation | Till the end of 20 weeks of gestation |
| The baseline characteristics of the study participants |
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Inclusion Criteria:
Exclusion Criteria:
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Poor responders women undergoing one of the following:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wael Elbanna Clinic | Cairo | Egypt |
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Recording the following for the four arms of the study: -age , body mass index in kg/m^2 |
| Before study intervention of the four arms (at day 2 in the ovulation induction cycle) |