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A Prospective cohort study including couples with poor responder females who undergoing ICSI
Purpose:
To determine the optimal embryonic stage for transfer in poor responders.
Method:
Patients were divided into day 3 transfer group and day 5 transfer group. All cases had the same stimulation protocol and planning to do fresh embryo transfer. Assessments will be at Day 1, Day 3 and Day 5/6 according to Gardner's criteria 1999. Embryological and clinical data were recorded and then analyzed using SPSS (version 23) statistical software.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cleavage stage transfer | Poor responders who transfer their embryos in cleavage stage on day 3 |
| |
| Blast stage transfer | Poor responders who transfer their embryos on blast stage on day 5/6 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cleavage stage transfer | Other | transferring embryos through ICSI procedures for poor responders on cleavage stage of embryonic development. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Live birth rate | percentage of cycles started with the intent of egg retrieval that led to a live birth. | delivery of healthy neonate after 37 weeks of pregnancy |
| Implantation rate | Percentage of the implanted embryos number for each group / number of transferred embryos. | 6 weeks of pregnancy |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate | Percentage of pregnant cases with fetal heart / transferred cases for each group | after 6 weeks of embryonic transfer |
| Cancellation rate | percentage of blast transfer cases who did not achieve blast stage (cancelled cases) / total number of blast stage cases |
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Inclusion Criteria:
Exclusion Criteria:
poor responders females with AMH≤ 1.2ng and have ≤ 5 mature oocytes
Poor responders undergoing ICSI procedures at Ganin fertility center in Egypt
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Manar M Hozyen, MSc. | Contact | +2001229483320 | manarnrc@gmail.com | |
| Amira Hassan, BSc. | Contact | manarnrc@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Manar Hozyen, MSc. | Ganin Fertility Center | Principal Investigator |
| Amira Hassan, BSc. | Ganin Fertility Center | Principal Investigator |
| Hanaa Elkhader, BSc. |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ganin fertility center | Recruiting | Cairo | 11728 | Egypt |
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| ID | Term |
|---|---|
| D007247 | Infertility, Female |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| Blast stage transfer | Other | transferring embryos through ICSI procedures for poor responders on blast stage of embryonic development. |
|
| 5:6 days of ICSI |
| Fertilization rate | Percentage of fertilized oocyte (appearance of two pronuclei) / Number of injected oocytes | 16:19 hours after intracytoplasmic injection(ICSI) |
| Cleavage rate | Percentage of cleaved embryos / Number of fertilized oocytes | 72 hours after ICSI |
| High quality day 3 embryos | High quality D3 embryos according to Gardner's criteria / total cleaved embryos | 72 hours after ICSI |
| Blast rate | Percentage of total blastocysts / Total cleaved embryos | 5:6 days of ICSI |
| High quality blast rate | Morphological grading of trophectoderm and Inner cell mass using Gardner's criteria 1999, from grade A and B ( A is the highest quality). Total high grade embryos/ total blast embryos. | 5:6 days of ICSI |
| Ganin Fertility Center |
| Principal Investigator |
| Hosam Zaki | Ganin Fertility Center | Study Chair |
| D000091662 | Genital Diseases |
| D007246 | Infertility |