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This study investigates the effectiveness of a 24-week mindfulness intervention in reducing symptoms in psoriasis patients with anxiety and depression.
An adapted MBCT intervention will be offered to people with psoriasis with depression and/or anxiety. 8-week long MBCT therapy will be held between August 2021 and Jan 2022, based on the adapted protocol. The MBCT intervention will consist of 30-minute weekly groups focused on teaching mindfulness techniques and ways to recognize cognitive patterns that can increase anxiety and/or depression. Participants will be recruited from the community, according to the eligibility criteria detailed below. For all participants, anxiety and/or depressive symptom severity(SAS/SDS), PASI,DLQI,(as measured with standardized, validated scales) will be compared baseline and weeks 2;4;8;12;16;20;24. Itch intensity ,itch perception ,quality of sleep, hours missing at work ,helpfulness of common itch therapies serve as the secondary outcome, using a paired t-test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants received MBCT once a week for 8 weeks | Experimental | Participants received MBCT once a week for 8 weeks. At the same time, the drug therapy for psoriasis was used . |
|
| Active comparator | Active Comparator | Only the drug therapy for psoriasis was used . |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| mindfulness-based cognitive therapy (MBCT) | Behavioral | Mindfulness- Based Cognitive Therapy (MBCT) It involves practicing to be present 'in the moment' and an attitude of non- judgmental acceptance with the aim to maintain awareness, disengaging oneself from strong attachment and thereby developing a greater sense of emotional balance and well-being. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline on the Psoriasis Area and Severity Index (PASI) | PASI a measurement that combines severity of lesions and the area affected in one score that ranges from 0 to 72 . | Baseline and Week 2;4;8;12;16;20;24 |
| Change from Baseline on the Dermatology Life Quality Index (DLQI) | The DLQI is a 10-item questionnaire measuring the effect of dermatological diseases on patients over the last week. The DLQI total score is the sum of each individual item score and ranges from 0 or 1 to 30 . | Baseline and Week 2;4;8;12;16;20;24 |
| Change from Baseline on the Self-rating Depression Scale (SDS) | In the main component of the SDS , patients are asked 20 questions about Mental and physical feelings of emotional experience, and the patients determine the quality of emotion by selecting one of the options: Occasionally=1, sometimes=2, often=3, and continuously=4. | Baseline and Week 2;4;8;12;16;20;24 |
| Change from Baseline on the Self-rating Anxiety Scale (SAS). | In the main component of the SAS , patients are asked 20 questions about Mental and physical feelings of emotional experience, and the patients determine the quality of emotion by selecting one of the options: Occasionally=1, sometimes=2, often=3, and continuously=4. The total score is multiplied by an integer of 1.25 to get the standard score. | Baseline and Week 2;4;8;12;16;20;24 |
| Measure | Description | Time Frame |
|---|---|---|
| Itch perception | Questions regarding situations in which the itch is especially bad (multiple choice options regarding day time, daily situations); objective assessment in which respondents are asked to select answers from the choices offered as a list | Baseline |
| Hours missing at work |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yan Zhou, professor | Contact | 0086-13379007762 | yanzhou7798@xjtu.edu.cn | |
| Yan Zhao | Contact | 0086-18626973745 | 2130315198@stu.xjtu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Yan Zhou, professor | First Affiliated Hospital Xi'an Jiaotong University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Affiliated Hospital of Xi'an Jiaotong University | Xi'an | Shaanxi | 710061 | China |
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| ID | Term |
|---|---|
| D011565 | Psoriasis |
| ID | Term |
|---|---|
| D017444 | Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| D000099025 | Mindfulness-Based Cognitive Therapy |
| ID | Term |
|---|---|
| D064866 | Mindfulness |
| D015928 | Cognitive Behavioral Therapy |
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
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|
| Antipsoriatic treatment | Other | The routine drug therapy for psoriasis. |
|
Approximate average hours missing at work due to itch per week from last visit. |
| Baseline and Week 2;4;8;12;16;20;24 |
| Helpfulness of common itch therapies | Questions regarding helpfulness of common itch therapies. | Baseline and Week 2;4;8;12;16;20;24 |
| D004191 |
| Behavioral Disciplines and Activities |