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Low dose compose to control presbyopia symptoms
A los dose compound including pilocarpine, brimonidine and oxymetazoline was use to control presbyopia symptoms compared to pilocarpine and brimonidine in low doses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PBO Investigational drug | Experimental | Pilocarpine, brimonidine, oxymetazoline combined with hyaluronic acid and bromfenac combined in an ophthalmic solution to be randomly instilled in one eye. |
|
| Pilocarpine | Active Comparator | Pilocarpine was instilled in the other oye. |
|
| Brimonidine | Active Comparator | Brimonidine was instilled in the other eye. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PBO to control presbyopia symptoms | Combination Product | Low dose PBO to control presbyopia symptoms |
|
| Measure | Description | Time Frame |
|---|---|---|
| Jaeger notation near uncorrected visual acuity change | Number of lines improved 1 hour after drug instillation | 1 hour |
| Comparison of PBO compound Jaeger notation improvement vs Pilocarpine or Brimonidine alone | Number of lines improve comparing PBO compound vs Pilocarpine or Brimonidine | 1 hour |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Cesar Alejandro S Galeana | Optall Vision | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Optall Vision | Mexico City | 01090 | Mexico |
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| ID | Term |
|---|---|
| D011305 | Presbyopia |
| ID | Term |
|---|---|
| D012030 | Refractive Errors |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D010862 | Pilocarpine |
| D000068438 | Brimonidine Tartrate |
| D010109 | Oxymetazoline |
| ID | Term |
|---|---|
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011810 | Quinoxalines |
| D006574 | Heterocyclic Compounds, 2-Ring |
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Pilocarpine, brimonidine, oxymetazoline (PBO) compound was instilled in the non-dominant eye of presbyopic patients, while in the dominant eye pilocarpine or brimonidine were instilled.
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While in office the care provider took a number out of a closed container. Number 1 was designated for the placebo; Number 2 was designated for the compound
|
| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |