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subjects with severe seasickness, who failed to habituate to sea conditions after at least six month of active sailing, were enrolled to the single-blind randomized control study. The intervention group was treated with rotatory chair stimulation at sinusoidal harmonic acceleration protocol coupled with galvanic vestibular stimulation to the mastoid processes. This unique procedure was hypothesized to promote habituation to seasickness. The control group underwent a sham procedure. All study participants filled out seasickness questionnaires at set time points following the intervention and underwent repeated step testing to determine their vestibular time constant. The number of anti-motion sickness clinic visits and scopolamine prescriptions was also recorded in the three months period following the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sham procedure | Sham Comparator | Participants with severe motion sickness were sited in the the rotatory chair with the videonystagmography recorder masking their eyes, while two galvanic vestibular stimulation electrodes were connected to the mastoid processes. No active stimulus was given. |
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| GVS stimulation coupled with inverse phase rotatory chair stimulation | Experimental | Participants with severe motion sickness were sited in the the rotatory chair with the videonystagmography recorder masking their eyes, while two galvanic vestibular stimulation electrodes were connected to the mastoid processes. The rotatory chair was activated in sinusoidal harmonic acceleration protocol in inverse phase to galvanic vestibular stimulation. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GVS stimulation coupled with inverse phase rotatory chair stimulation at sinusoidal harmonic acceleration protocol | Procedure | GVS stimulation coupled with inverse phase rotatory chair stimulation at sinusoidal harmonic acceleration protocol |
| Measure | Description | Time Frame |
|---|---|---|
| Vestibular time constant | Vestibular time constant was measured using repeated rotatory chair stimulation in step protocol. | Until one month following the intervention |
| Seasickness severity | Seasickness severity as determined by Wiker questionnaire at set time frames following the intervention | Until one month following the intervention |
| scopolamine drug prescription | scopolamine drug prescriptions were calculated for each participant and compared between the two groups | Until three months following the intervention |
| Anti-motion sickness clinic visits | Anti-motion sickness clinic visits were calculated for each participant and compared between the two groups | Until three months following the intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dror Tal, PhD | The Israel Naval Medical Institute, IDF Medical Corps, Haifa, Israel | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34782915 | Derived | Gutkovich YE, Lagami D, Jamison A, Fonar Y, Tal D. Galvanic vestibular stimulation as a novel treatment for seasickness. Exp Brain Res. 2022 Feb;240(2):429-437. doi: 10.1007/s00221-021-06263-w. Epub 2021 Nov 15. |
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| Sham procedure | Procedure | Participants with severe motion sickness were sited in the the rotatory chair with the videonystagmography recorder masking their eyes, while two galvanic vestibular stimulation electrodes were connected to the mastoid processes. No active stimulus was given. |
|
| ID | Term |
|---|---|
| D009041 | Motion Sickness |
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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