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With this retrospective observational cohort study, we performed a longitudinal assessment of the renal function of the adult CF patients who underwent LUTX, aiming 1) to describe possible risk factors associated with perioperative AKI and 2) to describe AKI short and long term effects on clinical outcomes.
This study is a retrospective analysis of prospectively collected data from medical records of all consecutive CF patients who underwent LUTX at our Institution from January 2013 to December 2018.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lung Transplantation | Procedure | Double lung transplant |
| Measure | Description | Time Frame |
|---|---|---|
| Acute Kidney Injury | AKI stage 1, stage 2, and stage 3 whether a 1.5-1.9 times, 2-2.9 times, and >3 times increase from the preoperative creatinine was measured, respectively. Following KIDGO criteria | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Survival | Death at follow-up | Until May 31 2021 |
| Measure | Description | Time Frame |
|---|---|---|
| Chronic Kidney Injury | chronic kidney disease (CKD) at 1-year follow-up was defined according to KIDGO criteria: an eGFR between 90 to 60 mL/min/1.73 m2 was considered to be stage 2 CKD, between 30-to-59 mL/min/1.73 m2 was considered to be stage 3 CKD, between mL/min/1.73 m2 was classified as stage 4, and < 15 mL/min/1.73 m2 (or need for dialysis or kidney transplant) was considered to be stage 5 | 1 year after lung transplantation |
Inclusion Criteria:
Exclusion Criteria:
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Adult patients undergone LUTX at a single Institution
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico | Milan | 20100 | Italy |
On request
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| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D016040 | Lung Transplantation |
| ID | Term |
|---|---|
| D013510 | Pulmonary Surgical Procedures |
| D019616 | Thoracic Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D016377 | Organ Transplantation |
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| D030342 |
| Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |
| D014180 | Transplantation |