Evaluation of acute kidney injury, renal recovery and development of chronic kidney disease in patients undergoing lung transplantation

It is well described that acute kidney injury and development of chronic kidney disease significantly impact short- and long-term survival after lung transplantation. However, there is limited data about prevalence of kidney disease according to current KDIGO consensus guidelines. It is the aim of this study to describe short- and long-term renal outcomes following lung transplantation. Selected patients who underwent prospective pretransplant renal functional reserve testing with high oral protein load will be analyzed separately in respect to occurrence of acute kidney injury following lung transplantation and development of chronic kidney disease.

For retrospective analysis for all patients undergoing lung transplantation:

Inclusion Criteria:

• Older than 18 years

Exclusion Criteria:

• Patients with eGFR <15ml/min/1.73m2 or with chronic dialysis treatment prior LTx
• Patients undergoing retransplantation and multiorgan transplantation

For prospective study involving patients with pretransplant renal functional reserve testing

Exclusion criteria:

• as above
• unable to perform renal functional reserve testing (e.g., due to critical illness)
• pre-existing acute kidney injury

All patients undergoing lung transplantation at University Hospital Giessen between 2003 and 2016. Subgroup of patients who underwent pretransplant renal functional reserve testing will be analyzed separately.