Early Warning Model of Susceptibility and High-risk Population of Cervical Cancer Related to HPV

Study on Early Warning Model of Susceptibility and High-risk Population of Cervical Cancer Related to HPV

Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Adopting a genome-wide approach, we aimed to establish an early warning model for a high-risk population of cervical cancer.

Inclusion Criteria:

• (1) Case group a) Aged 25-75 years. b) Han nationality. c) Patients with cervical cancer or cervical precancerous lesions above CIN2 diagnosed by biopsy or postoperative pathological diagnosis.
• (2) Control group: a) Aged 25-75 years. b) Han nationality. c) No family history of cervical cancer or precancerous lesions. d) The results of TCT examination showed no abnormality.

Exclusion Criteria:

• (1) suffering from other neoplastic diseases.
• (2) pregnant women.
• (3) those with a history of bone marrow transplantation.