HPV Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma

A Multi-omics Study on the Human Papillomavirus Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma

This study aims to analyze the multi-omics results between uterine cervical adenocarcinoma patients with and without human papillomavirus (HPV) infections. The multi-omics profiles include genome wide association study (GWAS), whole exome sequencing, analysis of transcriptomics and metabolomics. The HPV integration status is interpreted by GWAS. A comprehensive multi-omics will reveal the role of HPV integration in the molecular mechanism of tumorigenesis and prognosis of uterine cervical adenocarcinoma.

Inclusion Criteria:

• Confirmed primary adenocarcinoma of the uterine cervix
• Signed an approved informed consents
• Feasible for biopsy

Exclusion Criteria:

• Not meeting all of the inclusion criteria