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Gluten sensitivity is the most common auto-immune disease associated with auto-immune thyroiditis. This association is through elevated anti-Tissue transglutaminase (Anti-tTG) levels both in Celiac disease and thyroiditis. In our study we tried to find if there is any correlation in between Anti-tTG and degree of fibrosis in thyroid tissue (Post-operative specimen).
Most common auto-immune disease associated with Celiac disease is autoimmune thyroiditis. This association in between Celiac disease and aout-immune thyroiditis is related with asymptomatic rise in anti-tTG levels. In our study, we planned to show that if there is any correlation of thyroiditis related fibrosis in thyroid tissue with anti-tTG IgA ( immune-globulin A) and IgG (immune-globulin G).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Operated Patients | Experimental | Measurement of fibrosis degree and Anti-tTG levels |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Measuring of fibrosis in thyroid specimen and measuring of Anti-tTG in serum samples | Other | Examination of pathology specimen and laboratory measuring |
|
| Measure | Description | Time Frame |
|---|---|---|
| Amount of fibrosis in thyroid tissue and measured level of anti-tTG levels in serum | Degree of fibrosis was defined after painting of slides with masson trichrome as absent, mild, moderate semi-quantitatively. | one day after operation |
| Measurement of Anti-tTG levels in serum | Amount of serum Anti-TG in IU/mL | one day after operation |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gorkem Gundogan | Not Affliated | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| SBU Diskapi Yildirim Beyazit Training and Research Hospital | Ankara | 06110 | Turkey (Türkiye) |
Hospital records
June 2021 for 1 year
No criteria
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