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To investigate the effect of co existance of diabetes mellitus and chronic kidney disease on basic coagulation profile in comparison with diabetic patients with normal kidney function and non diabetic patients with chronic kidney disease
We will study impact of type 2 diabetes mellitus on basic coagulation profile and platelet indices among patients with chronic kidney disease
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Co existance of diabetes mellitus and chronic kidney disease | Study basic coagulation profile and platelet indices among those patients with combined diabetes mellitus and chronic kidney disease |
| |
| Diabetes mellitus without chronic kidney disease | Study basic coagulation profile and platelet indices among those patients with diabetes mellitus only |
| |
| Chronic kidney disease without diabetes mellitus | Study basic coagulation profile and platelet indices among those patients with chronic kidney disease without diabetes mellitus |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hematologic tests for patients with diabetes mellitus and chronic kidney disease | Diagnostic Test | Study basic coagulation profile and platelet indices among diabetic patients with chronic kidney disease |
| Measure | Description | Time Frame |
|---|---|---|
| Estimate risk of thrombosis or bleeding for the 3 study groups by prothrombin time | We will include 150 patients and classify them into 3 groups each one consists of 50 patients First group those patients with diabetes mellitus only Second group those patients with chronic kidney disease only Third group those patients with combined diabetes mellitus type 2 and chronic kidney disease not on hemodialysis First we will measure prothrombin time | 1 day |
| Estimate risk of thrombosis or bleeding for the 3 study groups by prothrombin concentration | We will include 150 patients classified into 3 groups as previous Second measure is prothrombin concentration | 1 day |
| Estimate risk of thrombosis or bleeding for the 3 study groups by INR | We will include 150 patients as previous Third measure is INR ( international normalised ratio ) | 1 day |
| Estimate risk of thrombosis or bleeding for the 3 study groups by partial thromboplastin time | We will include 150 patients as previous Fourth measure is partial thromboplastin time | 1 day |
| Estimate risk of thrombosis or bleeding for the 3 study groups by serum fibrinogen | We will include 150 patients as previous Fifth measure is serum fibrinogen level in the 3 groups | 1 day |
| Estimate risk of thrombosis or bleeding for the 3 study groups by mean platelet volume | We will include 150 patients as previous Sixth measure is mean platelet volume in the 3 groups | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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We will classify study population into 3 groups First group those population with only type 2 diabetes mellitus Second group is those population with chronic kidney disease only Third group is those population with combined type 2 diabetes mellitus and chronic kidney disease
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag University | Sohag | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19754305 | Background | Gundogan K, Bayram F, Capak M, Tanriverdi F, Karaman A, Ozturk A, Altunbas H, Gokce C, Kalkan A, Yazici C. Prevalence of metabolic syndrome in the Mediterranean region of Turkey: evaluation of hypertension, diabetes mellitus, obesity, and dyslipidemia. Metab Syndr Relat Disord. 2009 Oct;7(5):427-34. doi: 10.1089/met.2008.0068. | |
| 27013319 |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jan 10, 2024 | |
| Reset | Jun 28, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jan 10, 2024 | Jun 28, 2024 |
| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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Blood samples for coagulation profile and platelet indices
| Estimate risk of thrombosis or bleeding for the 3 study groups by platelet distribution width | We will include 150 patients as previous Seventh measure is platelet distribution width for the 3 groups | 1 day |
| Estimate risk of thrombosis or bleeding for the 3 study groups by plateletcrit | We will include 150 patients as previous Eighth measure is plateletcrit of the 3 study groups | 1 day |
| Odegaard AO, Jacobs DR Jr, Sanchez OA, Goff DC Jr, Reiner AP, Gross MD. Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes. Cardiovasc Diabetol. 2016 Mar 24;15:51. doi: 10.1186/s12933-016-0369-6. |
| 24955167 | Background | Ulutas KT, Dokuyucu R, Sefil F, Yengil E, Sumbul AT, Rizaoglu H, Ustun I, Yula E, Sabuncu T, Gokce C. Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: a marker for atherosclerosis? Int J Clin Exp Med. 2014 Apr 15;7(4):955-61. eCollection 2014. |